ACP1, acid phosphatase 1, 52

N. diseases: 107; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex. 15586390 2005
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE In this article, we confirm the positive association of acid phosphatase locus 1 (ACP1)*A/adenosine deaminase locus 1 (ADA1)*2 gametic type with type 1 diabetes (T1D) previously reported and show a negative correlation between the frequency of this gametic type with past malarial morbidity in Sardinia. 20805743 2010
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE In a registry-based group of 525 recent-onset IDDM patients <40 years old we investigated the possible interactions of a CTLA-4 gene A-to-G transition polymorphism with age at clinical disease onset and with the presence or absence of established genetic (HLA-DQ, INS VNTR) and immune disease markers (autoantibodies against islet cell cytoplasm (ICA); insulin (IAA); glutamate decarboxylase (GAD65-Ab); IA-2 protein tyrosine phosphatase (IA-2-Ab)) determined within the first week of insulin treatment.In new-onset IDDM patients. 9353155 1997
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE A comparative analysis of the data on Type 1 diabetes with previously obtained data on Type 2 diabetes shows an opposite pattern of relationship between ACP1 and metabolic parameters. 12640337 2003
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE We have now analysed the relationship between BMI and ACP1 in gestational diabetes and in women with type 1 diabetes. 19855922 2010
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Antibodies to glutamic acid decarboxylase (GAD65 [GADA]) and the intracellular portion of protein tyrosine phosphatase (IA-2(ic) [IA-2A]) were measured by similar, but not identical, methods in samples from participants in the Type 1 Diabetes Genetics Consortium (T1DGC). 20693189 2010
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE This investigation based on the biological effects of ACP1 and ADA1 on the immune system and on the known biochemical interaction between the two systems showed a significant interaction between the two system concerning susceptibility to type 1 diabetes. 19789510 2009
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE We examine here the interaction between smoking and ACP1 as a mediator of susceptibility to diabetic retinopathy in a sample of puerperae with type 1 diabetes. 12495297 2002
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner. 11912546 2002
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE The R620W polymorphism in the protein-tyrosine-phosphatase nonreceptor type 22 gene (PTPN22) confers susceptibility to type 1 diabetes (T1D) and other autoimmune diseases. 20510318 2010
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. 8798755 1996
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE ACP1 is also associated with Crohn's disease and type 1 diabetes: the relationship between this class (Th1) of immunological diseases and ACP1 depends on gender. 17284925 2007
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE Type 1 diabetes mellitus. Comparison between the association with PTPN22 genotype and the association with ACP1-ADA1 joint genotype. 25125338 2014