ACP1, acid phosphatase 1, 52

N. diseases: 107; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.030 GeneticVariation disease BEFREE After the analysis, no evidence of association of the ACP1 genetic variants was found with CD or UC. 22428720 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.030 Biomarker disease BEFREE ACP1 is also associated with Crohn's disease and type 1 diabetes: the relationship between this class (Th1) of immunological diseases and ACP1 depends on gender. 17284925 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.030 Biomarker disease BEFREE The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. 11381200 2000