RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.320 Biomarker disease BEFREE Our data suggest that BDNF-Rac1/RhoA pathway may be involved in attenuation of CUMS-induced behavioral and neuronal damage by Paeonol that may represent a novel therapeutic agent for depression. 29752492 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.320 Biomarker disease PSYGENET Taken together, our data identify epigenetic regulation of RAC1 in the NAc as a disease mechanism in depression and reveal a functional role for Rac1 in rodents in regulating stress-related behaviors. 23416703 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.320 Biomarker disease BEFREE Taken together, our data identify epigenetic regulation of RAC1 in the NAc as a disease mechanism in depression and reveal a functional role for Rac1 in rodents in regulating stress-related behaviors. 23416703 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.320 Biomarker disease PSYGENET NADPH oxidase- and mitochondrion-derived superoxide at rostral ventrolateral medulla in endotoxin-induced cardiovascular depression. 17448908 2007