RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Furthermore, 5 target genes of GALNT7 involved in these signaling pathways were identified, including Crk, Rac family small GTPase 1, STAT3, poliovirus receptor and Tenascin C. In summary, high expression of GALNT7 was associated with poor prognosis of glioma, and may be used as an effective biomarker of glioma. 30405766 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Our findings suggested that TUNAR played an anticancer role in glioma cells by upregulating miR-200a and inhibiting Rac1, and so might represent a potential therapeutic target for the treatment of human glioma. 29540255 2018
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Our data indicated that miR-451 relays environmental signals by upregulating the activity of AMPK signaling, thereby modulating the activation of mTOR and Rac1/cofilin which, in turn, play key roles in glioma cell proliferation and migration, respectively. 28440461 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE In conclusion, our data indicated that miR-142 inhibited the migration, invasion and MMP expression of glioma by targeting Rac1, and may represent a novel potential therapeutic target and prognostic marker for glioma. 28714015 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Thus, a novel XIST-miR-137-Rac1 pathway regulatory axis in glioma pathogenesis was revealed in the present study. 28469789 2017
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Cofilin‑1 (CFL‑1), which is regulated by the Rac1‑WAVE2‑Arp2/3 signaling pathway, may promote radioresistance in glioma. 27052944 2016
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, can stimulate glioma cell invasion via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the Rho guanosine triphosphatase family member Rac1. 23975833 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Given that Rac1 GTPase has been suggested to mediate the switch between elongated and rounded invasion, the functionality of the Rac1 morphology switch was evaluated in the glioma and neuroblastoma cells. 24337070 2014
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE These results confirm the view that geranylgeranylation is essential to the activity and localization of Rho family proteins and suggest that Rac1 is required for GGTase-I-mediated glioma growth. 23073905 2013
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Viability reduction and Rac1 gene downregulation of heterogeneous ex-vivo glioma acute slice infected by the oncolytic Newcastle disease virus strain V4UPM. 23586025 2013
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE TWEAK-treated glioma cells display an increased activation of Cdc42, and depletion of Cdc42 using siRNA abolishes TWEAK-induced Rac1 activation and abrogates glioma cell migration and invasion. 22571869 2012
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton. 21706053 2012
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Here, we show that the Rho family GTPase Rac1 is involved in the glioma stem-like cell (GSLC) maintenance and tumorigenicity in human glioma. 21704033 2011
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. 22080864 2011
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Furthermore, silencing the endogenous expression of RhoGDIα in glioma cells was found to be sufficient in abrogating the down-regulation of Rac1-GTP and the ensuing suppression of glioma cell motility induced by Sema5A. 20696765 2010
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE Taken together, these data suggest that ARF6-mediated Rac1 activation is essential for glioma cell invasion via a signaling pathway that requires IQGAP1. 19155310 2009
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease LHGDN Taken together, these data suggest that ARF6-mediated Rac1 activation is essential for glioma cell invasion via a signaling pathway that requires IQGAP1. 19155310 2009
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease LHGDN S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. 18088600 2008
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Inhibition of endogenous ELMO1 and Dock180 expression significantly impeded glioma cell invasion in vitro and in brain tissue slices with a concomitant reduction in Rac1 activation. 17671188 2007
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. 17018610 2006
CUI: C0017638
Disease: Glioma
Glioma
0.100 AlteredExpression disease BEFREE These data show that ephrin-B3 expression and signaling through Rac1 are critically important to glioma invasion. 16951161 2006
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease BEFREE These findings warrant further investigation to determine precisely how the modulation of Rac1 and ROCK can be exploited to inhibit glioma invasion. 16204049 2005
CUI: C0017638
Disease: Glioma
Glioma
0.100 Biomarker disease LHGDN Thus, functional analysis of Rac1 and Rac3 using RNA interference reveals a critical role for these GTPases in the invasive behavior of glioma and breast carcinoma cells. 16027728 2005