RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker disease BEFREE Active <i>BCR</i> related (<i>ABR</i>) gene deactivates ras-related C3 botulinum toxin substrate 1 (RAC1), which plays an essential role in regulating normal hematopoiesis and in leukemia. 29262589 2017
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease BEFREE Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction. 23726395 2013
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker disease BEFREE However, loss of either Rac1 or Rac2 is sufficient to impair survival and growth of the transformed MLL-AF9 leukemia. 21940819 2011
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease BEFREE We conclude that overexpression of Rac1 contributes to the accelerated migration and high proliferation potential of leukemia cells, which could be implicated in leukemia development and progression. 19563775 2009
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease LHGDN Murine leukemia virus particles activate Rac1 in HeLa cells. 16716260 2006
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker disease LHGDN These data suggest the presence of a novel protein complex of CrkL, DOCK2, and Vav to regulate Rac1 in leukemia cell lines. 12393632 2002
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker disease LHGDN Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid. 12027902 2002
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease LHGDN In the present study we provide evidence that arsenic trioxide induces activation of the small G-protein Rac1 and the alpha and beta isoforms of the p38 mitogen-activated protein (MAP) kinase in several leukemia cell lines. 12239215 2002