RAC1, Rac family small GTPase 1, 5879

N. diseases: 415; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE We found that the combined inhibition of Bcl-2/Bcl-xL and RAC1 resulted in synergistic pro-apoptotic and anti-migratory effects in a broad range of different glioblastoma cells. 30859392 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 AlteredExpression disease BEFREE Wnt5a expression and activations of RhoA, Cdc42, and Rac1 were detected in human glioblastoma tissues by using ELISA assays and small G-protein activation assays, respectively. 29207169 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE In summary, this investigation identifies an EGFR-DOCK180-RAC1-MLK3-JNK signaling axis that drives glioblastoma cell migration and dissemination.<b>Implications:</b> On the basis of these findings, MLK3 emerges as a potential therapeutic target for the treatment of glioblastoma.<i></i>. 28487380 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE We have previously reported that combined inhibition of the epidermal growth factor receptor by erlotinib and of RAC1 by NSC23766 yielded a synergistic antiproliferative effect on established and primary cultured glioblastoma cells. 28271323 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE We confirmed that simvastatin caused the translocation of the small Rho GTPases RhoA, Cdc42, and Rac1/2/3 from cell membranes to the cytosol in U251 (glioblastoma), A549 (lung adenocarcinoma) and MDA-MB-231(breast cancer). 28344327 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE In conclusion, not only Rac1 but also Rac2 and 3 are important for glioblastoma tumorigenesis and can serve as the potential therapeutic targets against glioblastoma and its stem-like cells. 28160553 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE Furthermore, Gab1 is required for HGF-induced Dock7 and Rac1 activation and glioblastoma cell invasion. 24518591 2014
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE We found that the presence of TIP-1 protein is essential to the intracellular redistribution of ARHGEF7 and rhotekin, one Rho effector and the spatiotemporally coordinated activation of Rho GTPases (RhoA, Cdc42 and Rac1) in migrating glioblastoma cells. 23563176 2014
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. 23283986 2013
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 AlteredExpression disease BEFREE TNF-like weak inducer of apoptosis (TWEAK)-Fn14 ligand-receptor signaling is one mechanism in GB that promotes cell invasiveness and survival and is dependent upon the activity of multiple Rho GTPases, including Rac1. 23775076 2013
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines. 23736154 2013
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE We previously reported that binding of the multifunctional cytokine TNF-like weak inducer of apoptosis (TWEAK) to its receptor fibroblast growth factor-inducible 14 (Fn14) induces glioblastoma cell invasion via Rac1 activation. 22571869 2012
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE Our results suggest that the difference in the activity balance of Rac1 and Cdc42 versus RhoA determines the mode of glioblastoma invasion and that Zizimin1 contributes to the invasiveness of glioblastoma cells with high Rac1 and Cdc42 activities. 22399802 2012
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 GeneticVariation disease BEFREE Thus, neurofibromin-deficient glioblastoma and mouse fibroblasts are enriched in Rac1-GTP, p-Pak1, p-LIMK1 and p-cofilin, with all proteins exhibiting decreased expression upon expression of NF1(1-1163) polypeptide. 19666124 2009
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE Here we report that human Mena (hMena) colocalizes with Rac1 in lamellipodia, and using an unmixing assisted acceptor depletion fluorescence resonance energy transfer (u-adFRET) analysis that hMena associates with Rac1 in vivo in the glioblastoma cell line U251MG. 19277120 2009
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.100 Biomarker disease BEFREE Suppression of Rac1 also induced apoptosis in 19 of 21 short-term cultures of human primary cells from grades II and III oligodendroglioma and grade IV glioblastoma that varied in p53, epidermal growth factor receptor, epidermal growth factor receptor vIII, MDM2, and p16/p19 mutational or amplification status. 11929835 2002