RECQL, RecQ like helicase, 5965

N. diseases: 58; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 AlteredExpression group BEFREE At the protein level, low nuclear RECQL1 level was associated with larger tumor size, lymph node positivity, high tumor grade, high mitotic index, pleomorphism, dedifferentiation, ER negativity, and HER-2 overexpression (P < 0.05). 27837030 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos. 28878163 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE Targeting RECQL associated tumors with novel DNA repair inhibitors may provide a new strategy for anti-cancer therapy. 26125302 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE Collectively, our findings identify a novel function of RECQ1 in gene regulation and indicate that RECQ1 contributes to tumor development and progression, in part, by regulating the expression of key genes that promote cancer cell migration, invasion and metastasis. 25483193 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.050 Biomarker group BEFREE Current data show that the specific depletion of the human RECQ1 helicase leads to mitotic catastrophe in cancer cells and inhibition of tumor growth in mice. 21752281 2011