Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.070 Biomarker disease BEFREE Patients with obesity and type 2 diabetes showed increased hepatic ghrelin O-acyltransferase transcripts as well as an increased hepatic apoptosis, pyroptosis, and compromised autophagy. 30137403 2019
CUI: C0028754
Disease: Obesity
Obesity
0.070 AlteredExpression disease BEFREE Recent studies suggest that decreasing the circulating octanoylated ghrelin level through the inhibition of GOAT activity, or simply by modulating the availability of its C8:0 substrate, might constitute a therapeutic strategy against obesity. 30103923 2018
CUI: C0028754
Disease: Obesity
Obesity
0.070 Biomarker disease BEFREE In addition, GOAT KO mice fed a medium-chain triglyceride (MCT) + high-sucrose diet showed a marked resistance to obesity and reduced feed efficiency. 28652538 2017
CUI: C0028754
Disease: Obesity
Obesity
0.070 Biomarker disease BEFREE Overall, inhibition of GOAT is a novel strategy for treatment of obesity and related metabolic disorders. 26732975 2016
CUI: C0028754
Disease: Obesity
Obesity
0.070 Biomarker disease BEFREE However, when fed on high-fat, high-sucrose diet, GOAT KO mice showed significantly reduced food intake and marked resistance to obesity, leading to amelioration of glucose metabolism. 26645250 2016
CUI: C0028754
Disease: Obesity
Obesity
0.070 AlteredExpression disease BEFREE Jejunum samples from humans with obesity showed a higher expression of GOAT (mRNA and protein), TPH1, and SERT mRNA compared with the nonobese humans (all P < 0.05). 26381270 2015
CUI: C0028754
Disease: Obesity
Obesity
0.070 Biomarker disease BEFREE GOAT may provide a critical molecular target in developing novel therapeutics for obesity and type 2 diabetes. 20038570 2009