C1QBP, complement C1q binding protein, 708

N. diseases: 111; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 AlteredExpression phenotype BEFREE HABP1 might be an independent predictive factor for breast cancer prognosis and up-regulation of HABP1 might play an important role in the metastasis of breast cancer. 19565630 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker phenotype BEFREE C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells. 28428626 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker phenotype BEFREE Complement component 1, q subcomponent binding protein (C1QBP) can mediate growth factor-induced cancer cell chemotaxis and distant metastasis by activation of receptor tyrosine kinases. 28608366 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 AlteredExpression phenotype BEFREE Furthermore, C1QBP was observed to be overexpressed in breast cancer tissues, and its expression level was closely linked with distant metastasis and TNM stages. 23924515 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker phenotype BEFREE Hyaluronic acid binding protein 1 (HABP1/gC1qR/p32), a ubiquitous multifunctional protein belonging to the hyaladherin family, has been implicated in the tumorigenesis, progression, invasion, and metastasis of several malignant tumors. 25355598 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker phenotype BEFREE Recent studies have proved beyond any doubt about the involvement of the ubiquitous, myriad ligand binding, multi-functional human protein, hyaluronan-binding protein 1 (HABP1), which is identical to the splicing factor associated protein (p32) and the receptor of the globular head of the complement component (gC1qR) in tumorigenesis and cancer metastasis. 29535843 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 AlteredExpression phenotype BEFREE The results showed that HABP1 overexpression correlated with higher histological grade (P = 0.004), advanced TNM stage (P = 0.008), greater tumor size (P = 0.016), metastasis of lymph node (P < 0.001), and recurrence (P = 0.040). 25794640 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker phenotype BEFREE We therefore conclude that cell-surface gC1qR regulates lamellipodia formation and metastasis via receptor tyrosine kinase activation. 21536672 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker phenotype BEFREE While gC1qR promotes tumor cell survival by enhancing angiogenesis and metastasis and also by contributing to the hypercoagulable and prothrombotic microenvironment, cC1qR/CR expression represents a pro-phagocytic "eat-me" signal through which cC1qR/CR expressing tumor cells are tagged for destruction by macrophages. 25044096 2014