TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease GENOMICS_ENGLAND
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease GENOMICS_ENGLAND
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease RGD This research aimed to study the effectiveness of human CD34+ hematopoietic stem cell on Wnt4 and P53 genes expression, histopathological grading and hepatic progenitor cells percentage in HCC rat model. 29429512 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease HPO
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN In contrast, p53 mutations occurred more frequently in advanced HCCs (p=0.041). 12168936 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression disease LHGDN Expression of p53 was observed in 30% of the non-tumorous and in 53% of the neoplastic tissue obtained from patients with HCC, with no differences between HCV and HBV. 16255765 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression disease LHGDN Thus, p53 loss of function in HCC should be evaluated both by p53 mutation analysis and p53 protein expression, as both give complementary information about p53 status. 15500550 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease LHGDN Also, the overall survival of patients with HCC with reference to p53 antibody level was studied. 18616935 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN Recently, it has been reported that exposure of the wild-type p53 human lymphoblastoid cell line to 4-HNE causes a high frequency of G to T transversion mutations at the third base of codon 249 (-AGG*-) in the p53 gene, a mutational hotspot in human cancers, particularly hepatocellular carcinoma. 12419825 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression disease LHGDN Relationship between therapeutic efficacy of arterial infusion chemotherapy and expression of P-glycoprotein and p53 protein in advanced hepatocellular carcinoma. 16521213 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN The prevalence of the p53 codon 249 mutation was expressed as a percentage amplifiable DNA samples analyzed from HCC patients while that of controls was expressed in the same way. 19034233 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN These data show that the 249(Ser) p53 mutation in plasma is strongly associated with hepatocellular carcinoma patients in Qidong area and the mutation should be screened as a new early diagnostic marker for HCC. 12767266 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN The incidence of point mutation of p53 codon 249 is lower in hepatocellular carcinoma and the heterozygous mutation of p53 exon7 found in these patients only indicate that they have genetic susceptibility to HCC. p53 codon 249 is a hotspot of p53 exon7 point mutation, suggesting that the point mutation of p53 exon 7 may not play a major role in the carcinogenesis of HCC in Anhui Province, a non-HCC-prevalent area in China. 12046074 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease LHGDN The results showed that p53 over-expression is a reliable marker for mutational modulation of p53 function. p53 was negatively correlated with p21/WAF1 in hepatitis B virus-related HCC (p=0.024, r=-0.432). 15201954 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN We clarified genome-scale chromosomal copy number alteration profiles and mutational statuses of p53 and beta-catenin in 87 HCC tumors. 17983802 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN Combined MDM2 G/G and p53 Pro/Pro had a synergistic effect on HCC risk, with an OR of 20.78 (P < 0.001). 18390844 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN We found this mutation was also detected, although it was at a much lower frequency, in plasma DNA of Qidong cirrhotics and healthy controls; We consider that these findings, together with the usual method of HCC diagnosis, will give more information in early diagnosis of HCC, and 249(Ser) p53 mutation should be developed to a new early diagnostic marker for HCC. 12679912 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN Loss of heterozygosity on chromosome 10q22-10q23 and 22q11.2-22q12.1 and p53 gene in primary hepatocellular carcinoma. 15222050 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN The P allele of the p53 R72P polymorphism has an increased risk for HCC in HbsAg-negative subjects, and exerts a synergistic influence on the risk for HCC when combined with HCC family history and the male gender. 16331559 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression disease LHGDN Here, we show that TIP30, also called CC3, regulates p53 mRNA stability and induces apoptosis by sensing of intracellular oxidative stress in human hepatocellular carcinoma (HCC) cells. 18519672 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease LHGDN In conclusion, serum concentration of p53 protein may be a convenient and useful non-invasive screening test for prediction of HCC. 16681440 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease LHGDN Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure. 18467159 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN AFB(1) frequently induces G:C to T:A transversions at the third base in codon 249 of TP53 and cooperates with HBV in causing p53 mutations in HCC. 17401425 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression disease LHGDN Also, p53 is implicated in the poor prognosis of HCV-HCC and could be used as a predictive marker to assess the prognosis of HCC patients. 18689267 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease LHGDN The cell death induced by Ad/AFPtBid in HCC cells is via an apoptotic pathway that can be independent of p53 status. 16708390 2006