TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Second, we present a meta-analysis, using our results along with those from 48 published studies, that examines the interrelationships among aflatoxin exposure, HBV infection, and p53 mutations in HCCs. 11401911 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Therefore, p53 mutation in the primary lesion is useful as an indicator of the biological behavior of recurrent hepatocellular carcinomas. 12800224 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Abnormalities of the RB tumor suppressor gene have been found in 20-25% of HCCs, including 80-86% of HCCs with p53 mutations. 8046425 1994
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE No p53 gene alterations were found in smaller HCC (< 3 cm) or at earlier stages. 8100480 1993
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE We examined tumors from five vinyl chloride-exposed patients, four with ASL and one with hepatocellular carcinoma (HCC), for evidence of MDM2 proto-oncogene amplification or p53 mutation in exons 5-8. 8293534 1994
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE To detect the status of loss of heterozygosity (LOH) in HCC and to determine the minimum region of LOH on 17p13.3, we analyzed 22 paired HCC and non-cancerous liver samples with 14 polymorphic markers plus TP53 (p53 gene) as a comparison. 12565177 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE In xenograft models, mice bearing TP53-mutated or TP53-deleted human HCCs were hypersensitive to treatment with conformation-changing AURKA inhibitors, thus suggesting a therapeutic strategy for this subgroup of human HCCs. 27213815 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE We analyzed human hepatocellular carcinoma (HCC) by ISH for chromosome 17 and investigated the correlation of its copy number with histologic malignancy, proliferative activity, p53 mutation, and DNA ploidy. 8625234 1996
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE In conclusion, LOH and P53 protein overexpression, rather than mutations in the p53 or beta-catenin genes or MSI, seem to be involved in the spreading of HCC, suggesting the presence of metastasis suppressor genes in the vicinity of the chromosomal loci in question. 12640682 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE A single base substitution at the third nucleotide of codon 249 of TP53 (R249S) is common in HCC in these regions and has been associated with aflatoxin-DNA adducts. 19366907 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease LHGDN In contrast, p53 mutations occurred more frequently in advanced HCCs (p=0.041). 12168936 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE In this study, we described an alternative strategy named as trans-splicing that repaired mutant p53 transcripts in hepatocellular carcinoma (HCC) cells. 25732051 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Using the MiSeq™ system, plasma and matched tumor DNA samples were analyzed for hotspot mutations in the TERT, CTNNB1, and TP53 genes that had been verified as the most prevalent mutations in HCC. 27248174 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE We also used these methods to search for mutations in the P53 gene in patients with hepatocellular carcinoma. 10533071 1999
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE These results suggest that alterations of p53 may be important events in the genesis of HCCs and that point mutation may precede allele loss. 1311638 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE To detect p53 mutations in circulating DNA (cirDNA) of transplanted hepatocellular carcinoma (HCC) patients could be an interesting approach to know of any tumor recurrence. 27753013 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas. 1670994 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Mutations of the tumor-suppressor gene p53 have been found in 30-50% cases of hepatocellular carcinoma (HCC). 10402169 1999
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE In vitro, Transwell and doxorubicin (DOX)-induced apoptosis assays revealed that GSTM1 showed opposite functions in different HCC cell lines with varied TP53 genotype statuses. 31605953 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE We searched for pathogenic variants in TP53 in a 14 year-old female diagnosed with fibrolamellar hepatocellular carcinoma, a rare subtype of hepatocellular carcinoma. 28477317 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma. 15044920 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE FASAY is a sensitive method for detecting the various types of p53 mutations in HCC, suggesting that the yeast functional assay for the detection of p53 mutations may be essential for elucidating their clinical significance. 17266182 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Because our results suggest for the first time that the Pro/Pro homozygote of p53 Arg72Pro polymorphism may be a genetic susceptibility factor for HCC (especially in the male gender and HBV-infected patients) in the Turkish population, further independent studies are required to validate our findings in a larger series, as well as in patients of different ethnic origins. 21607615 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Analysis of the cellular origin of hepatocellular carcinoma by p53 genotype. 8954175 1996
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE These findings show that p53 mutations are infrequently involved in the malignant transformation of hepatocytes in an area of low hepatocellular carcinoma prevalence. 1332921 1992