TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 CausalMutation disease CLINVAR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease HPO
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 CausalMutation disease CGI
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease GENOMICS_ENGLAND
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease GENOMICS_ENGLAND
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease BEFREE Mutant p53 protein was detected in the nuclei of HCCs from 14 (61%) of 23 patients from China and from three (30%) of 10 patients and six (60%) of 10 patients, respectively, from the two regions of the United States. 1279184 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE These results suggest that alterations of p53 may be important events in the genesis of HCCs and that point mutation may precede allele loss. 1311638 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease BEFREE We have examined 13 cases of human hepatocellular carcinomas from Germany for the presence of p53 aberrations in exons 4 to 8 of the gene by single-strand conformation polymorphism and restriction fragment-length polymorphism analyses and by sequencing of polymerase chain reaction products. 1317262 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma. 1319827 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE A mutational "hotspot" in the p53 gene in human hepatocellular carcinomas has been identified that could reflect exposure to a specific carcinogen, one candidate being aflatoxin B1. 1324739 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Mutation of p53 gene in hepatocellular carcinoma in Taiwan. 1327523 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas. 1329103 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Therefore, p53 gene mutation is suggested to occur independently of the type of viral infection or status of preexisting liver disease and to occur preferentially in moderately and poorly differentiated HCCs in association with or after loss of another p53 allele as a late event of HCC progression. 1330291 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE These findings show that p53 mutations are infrequently involved in the malignant transformation of hepatocytes in an area of low hepatocellular carcinoma prevalence. 1332921 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker disease BEFREE By the PCR-SSCP analysis of DNAs from surgical specimens of human cancers, mutated ras genes (17%) and aberrations of tumor suppressor p53 gene (53%) including loss of one of the two alleles and a mutation in the remaining allele were detected in lung carcinomas and aberrations of both of the p53 and retinoblastoma (RB) genes were detected exclusively in advanced hepatocellular carcinomas. 1339101 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Abnormalities of the p53 gene have been identified in many malignancies, with reports of aberration in over half of colorectal, lung, breast and hepatocellular carcinoma cases. 1555884 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Structural abnormalities of the p53 gene were observed in eight of the 22 advanced HCCs, but in none of the early HCCs. 1655254 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas. 1670994 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Here we report on allelic deletions from chromosome 17p and mutations of the p53 gene found in 50% of primary HCCs from southern Africa. 1672732 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE A codon 249 mutation of the p53 gene identifies an endemic form of HCC strongly associated with dietary aflatoxin intake. 1682737 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression disease BEFREE Steady state levels of p53 specific RNA in primary hepatomas are practically indistinguishable from those in normal adult liver. 1847999 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE Mutational hotspot in the p53 gene in human hepatocellular carcinomas. 1849234 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE For example, an informative p53 mutational spectrum of frequent G----T transversions in codon 249 is found in hepatocellular carcinomas from either Qidong, People's Republic of China, or southern Africa. 1884379 1991
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 AlteredExpression disease BEFREE We conclude that the loss of p53 expression or the presence of abnormal forms of the protein are frequently associated with HCC cell lines. 2155427 1990
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 GeneticVariation disease BEFREE These results suggest that the mutations of p53 gene of HCC might be an independent prognostic predictor to help in the selection of candidates who should undergo more intensive postoperative treatment. 7489977 1995