PRDM2, PR/SET domain 2, 7799

N. diseases: 115; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE These results identify Akt3 as a target of RIZ1 regulation and expand our understanding of the Akt pathway in cancer and obesity. 29367689 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE The chromatin modifier <i>PRDM2/RIZ1</i> is inactivated by mutation in several forms of cancer and is a putative tumor suppressor gene. 29228717 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 AlteredExpression group BEFREE Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2. 19746436 2009
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 GeneticVariation group BEFREE The frequency of cancer-related gene methylation in SCCs was: CDH1 (95%), p16 (20%), p14 (15%), DAPK1 (15%), MGMT (15%), RB1 (5%), RASSF1 (5%), p15 (0%), PTEN (0%), PRDM2 (0%) and p53 (0%). 17034532 2006
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE The tumor suppressor gene RIZ in cancer gene therapy (review). 11748455 2002
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 GeneticVariation group BEFREE Our observations reinforce the yin-yang notion of RIZ gene products in human cancer and suggest a RIZ1 tumor suppressor role in hepatoma. 10508492 1999
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE This yin-yang imbalance in the amount of the two RIZ products may be an important cause of malignancy. 10369808 1999
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker group BEFREE The human PRDI-BF1 or BLIMP1 gene and its mouse homolog Blimp1 are members of the recently realized PR domain family that includes the retinoblastoma interacting zinc finger gene RIZ and the MDS1-EVI1 leukemia cancer gene. 8921366 1996