PRDM2, PR/SET domain 2, 7799

N. diseases: 115; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE Moreover, knockdown of DNMT1 by siRNA restored RIZ1 expression in HCC cell SMMC-7721 and reduced methylated CpG sites of RIZ1. 28339081 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. 20675009 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease LHGDN In other words, 4 HCCs showed the biallelic inactivation of the RIZ1. 18712668 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE In other words, 4 HCCs showed the biallelic inactivation of the RIZ1. 18712668 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE SMYD3 over-expression in HCC was associated with RIZ1 hypermethylation and mRNA down-expression. 17963297 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 PosttranslationalModification disease LHGDN Consequently, SMYD3 down-expression with RIZ1 de-methylation strongly inhibited hepatoma cell growth (MTT inhibitory rates: Pgenesil-1-s1 60.95% +/- 7.97%, Pgenesil-1-s2 72.14% +/- 9.68% vs Pgenesil-1-hk 6.89% +/- 4.12%, P < 0.01) and migration (Pgenesil-1-s1 4.24% +/- 1.58%, Pgenesil-1-s1 4.87% +/- 0.73% vs Pgenesil-1 19.03% +/- 4.63%, Pgenesil-1-hk 19.95% +/- 5.21%, P < 0.01) and induced apoptosis (FCM subG1 phase Pgenesil-1-s1 19.07% +/- 1.78%, Pgenesil-1-s2 17.68% +/- 2.36% vs Pgenesil-1 0.47% +/- 0.12%, Pgenesil-1-hk 1.46% +/- 0.28%, P < 0.01. 17963297 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 Biomarker disease BEFREE Frequent promoter hypermethylation and subsequent loss of protein expression has also been demonstrated in HCC at tumor suppressor gene (TSG), p16, p14, p15, SOCS1, RIZ1, E-cadherin and 14-3-3 sigma. 16706806 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 GeneticVariation disease BEFREE By analysing the Pro704-deletion polymorphism, we detected LOH of RIZ in 31 of 79 (39%) informative HCC cases, 11 of 47 (23%) colon cancer cases, 8 of 43 (19%) breast cancer cases, 8 of 66 (12%) stomach cancer cases. 11259086 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 PosttranslationalModification disease BEFREE Our data suggest that the RIZ locus is a target of frequent deletion in HCC, but that the more common way of RIZ inactivation in HCC may not involve mutations that alter peptide sequences. 10862032 2000
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE RIZ1 transcript was undetectable in 80% of hepatoma cell lines (8 of 10 lines examined). 10508492 1999