CCDC6, coiled-coil domain containing 6, 8030

N. diseases: 156; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.060 Biomarker group BEFREE We retrospectively reviewed 16 patients with RPLN metastasis of PTC who underwent therapeutic dissection of RPLN metastases. 31004196 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.060 GeneticVariation group BEFREE TERT promoter mutations correlated with older age (P < 0.0001), larger tumor size (P = 0.0002), oxyntic and aggressive PTC variants (P = 0.01), higher tumor stages (P < 0.0001), distant metastases (<0.0001) and disease outcome (P < 0.0001). 31042674 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.060 Biomarker group BEFREE The aim of this study was to identify all published cases of PTC and FTC muscle metastases and derive the true incidence of this malignancy. 29731874 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.060 AlteredExpression group BEFREE CR = complete response; DM = distant metastases; DTC = differentiated thyroid cancer; ETE = extra-thyroidal extension; M0 = detected during follow-up; M1 = detected at diagnosis; MSKCC = Memorial Sloan Kettering Cancer Center; NED = no evidence of disease; OS = overall survival; PFS = progression free survival; PTC = papillary thyroid cancer; RAI = radioactive iodine; Tg = thyroglobulin. 28704099 2017
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.060 Biomarker group BEFREE Although controversy continues about the appropriate surgical management of PTC, total thyroidectomy is usually indicated given the frequent multicentricity and metastases of the disease, which in turn, necessitates adjuvant RAI and careful surveillance. 16882499 2006
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.060 GeneticVariation group BEFREE The expression of CD82 and CD63 was analysed by reverse transcriptase-PCR (RT-PCR) and immunohistochemistry in benign goiter (n=12) and 75 primary thyroid carcinoma tissue specimens (PTC: 33, FTC: 24, UTC: 18) out of which 36 were non-metastasized primary tumors and 39 were metastasized tumors (regional lymph node and/or distant metastases). 15375577 2004