ANGPTL6, angiopoietin like 6, 83854

N. diseases: 48; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.240 Biomarker disease BEFREE Specially, bANGPTL6β gene probably contributes to a new target for treatment of obesity and obesity-related diseases. 31102716 2019
CUI: C0028754
Disease: Obesity
Obesity
0.240 AlteredExpression disease BEFREE Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. 29852166 2018
CUI: C0028754
Disease: Obesity
Obesity
0.240 AlteredExpression disease BEFREE Baseline ANGPTL6 levels in patients with obesity and T2DM did not differ from the control group. 27135654 2017
CUI: C0028754
Disease: Obesity
Obesity
0.240 GeneticVariation disease BEFREE Further validation in cohorts with severe obesity and engineering the variants in model organisms will be needed to explore whether human variants in ANGPTL6 and other genes that lead to obesity when deleted in mice, do contribute to obesity. 28663568 2017
CUI: C0028754
Disease: Obesity
Obesity
0.240 Biomarker disease MGD This study establishes AGF as a new hepatocyte-derived circulating factor that counteracts obesity and related insulin resistance. 15778720 2005