ZNRF3, zinc and ring finger 3, 84133

N. diseases: 41; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE Nuclear accumulation of β-Catenin, increased expression of Cyclin D1 and significantly higher expression of AXIN2 (p = 0.0039), ZNRF3 (p = 0.0032) and LEF1(p = 0.0090) observed in the tumours harbouring the deletion in comparison to tumours without CTNNB1 mutation demonstrates that the truncated β-Catenin is functionally active and erroneously activates the downstream targets. 29872083 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE SCF<sup>β-TRCP</sup> E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. 29497989 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE We investigated mutation of the ubiquitin ligases RNF43 and ZNRF3 as alternate mechanism of altering the Wnt signal in serrated colorectal neoplasia. 27661107 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE Taken together, these results provide insight into a potential tumor suppressor role of ZNRF3 in PTC progression, and may have potential clinical relevance for the prognosis and treatment of PTC. 27448298 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 GeneticVariation group BEFREE Exome sequencing identified new major drivers in all tumor types, including KCNJ5, ATP1A1, ATP2B3 and CACNA1D mutations in aldosterone-producing adenomas (APA), PRKACA mutations in cortisol-producing adenomas (CPA), ARMC5 mutations in primary bilateral macronodular adrenocortical hyperplasia (PBMAH) and ZNRF3 mutations in adrenocortical carcinomas (ACC). 26739091 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 GeneticVariation group BEFREE Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. 26023187 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 AlteredExpression group BEFREE We observed a clear relationship between ZnRF3 expression in paracancerous tissue and tumor size. 27352324 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE ZNRF3, encoding a cell surface E3 ubiquitin ligase, was the most frequently altered gene (21%) and is a potential new tumor suppressor gene related to the β-catenin pathway. 24747642 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma. 23504200 2013