SELENOI, selenoprotein I, 85465

N. diseases: 29; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.070 Biomarker disease BEFREE Using reverse phase protein array, Western blot, Super TOP/FOP, confocal microscopy, and sphere formation ability (SFA) assays, we identified the AKT and Wnt signaling pathways as the key targets of aprepitant in three human HB cell lines (HepT1, HepG2, and HuH6). 26516161 2015
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.070 Biomarker disease BEFREE We assessed β-catenin and Yap1 signaling and interactions in hepatoblastoma cell lines ((HuH6, HepG2, HepT1, HC-AFW1, HepG2, and HC-AFW1); proteins were knocked down with small interfering RNAs, and effects on proliferation and cell death were measured. 24837480 2014
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.070 Biomarker disease BEFREE Human HB cell lines HepT1, HepG2, and HuH6, human tumor samples from 17 children with HB as well as mice xenografted with human HB cell line HuH6 were analyzed regarding the SP/NK1R complex as a potential new anti-tumor target in HB. 24412605 2014
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.070 Biomarker disease BEFREE Both HB cell lines HUH6 and HepT1 were xenotransplanted in NMRI mice (nu/nu) and 2 cycles of cisplatin (CDDP) treatment were administered. 21132272 2011
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.070 Biomarker disease BEFREE Transduction rates were 87.8% (+6.7) in the mixed HB cell line HUH6, 98.6% (+1.4) in the epithelial HB cell line HepT1 and 93.6% (+0.6) in the multifocal HB embryonal cell line HepT3, respectively. 19213079 2009
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.070 AlteredExpression disease BEFREE Bcl-2 expression was analyzed in the HB cell lines HUH6 and HepT1 as well as in the HCC cell line HepG2 before and after treatment with cisplatin, doxorubicin, taxol, and etoposid. 17574594 2008
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.070 Biomarker disease BEFREE A continuous cell line (HepT1) was established from a human hepatoblastoma with predominant embryonal differentiation. 8606490 1996