Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 GeneticVariation group BEFREE Among the MDN cases, histories of radiation exposure, therapy-related myeloid neoplasms after successful treatment for acute promyelocytic leukemia, and leukemic transformation of myeloproliferative neoplasms have been reported to have a strong association with RUNX1 mutations. 21268063 2011
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 Biomarker group BEFREE Overexpression of transcription factors runt-related transcription factor 1 (RUNX1) and nuclear factor, erythroid-derived 2 (NF-E2) was reported in granulocytes of patients with polycythemia vera and other myeloproliferative neoplasms (MPNs). 24297870 2014
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 GeneticVariation group BEFREE AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms. 19850737 2009
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 Biomarker group BEFREE Three were AML cases belonging to either AML-M5a or AML-1 subtypes and one was a myeloproliferative disorder. 11376807 2001
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 Biomarker group HPO
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 Biomarker group BEFREE Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bone marrow failure and myeloproliferative disorder. 25066130 2014
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 AlteredExpression group BEFREE AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. 20339092 2010
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 GeneticVariation group BEFREE A ZMYM2-FGFR1 8p11 myeloproliferative neoplasm with a novel nonsense RUNX1 mutation and tumor lysis upon imatinib treatment. 23751892 2013
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 AlteredExpression group BEFREE Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice. 15477599 2004
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 AlteredExpression group BEFREE Increased EVI-1 gene expression has been detected in a number of myeloproliferative disorders including MDS, AML, blast crisis of CML, and more recently in the peripheral blood of some JMML patients. 9447818 1997
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.200 GeneticVariation group BEFREE In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with mutations in RUNX1. 22201794 2012