Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Chromosomal abnormalities, such as t(9;22)(q34;q11) (ABL/BCR), t(12;21)(p13;q22) (TEL/AML1), and t(11q23) (MLL) are independent prognostic indicators in childhood acute lymphoblastic leukemia resulting in risk adapted therapy. 19875970 2009
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. 19047175 2008
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Chromosome translocation to generate the TEL-AML1 (also known as ETV6-RUNX1) chimeric fusion gene is a frequent and early or initiating event in childhood acute lymphoblastic leukemia (ALL). 19287094 2009
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Clinical parameters and ETV6-RUNX1 status (using FISH technique) of pALL patients attending the Pediatric Oncology Clinic, King Abdulaziz Medical City, Riyadh from 2006 to 2011 were studied. 26625756 2015
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Cluster analysis of genomic ETV6-RUNX1 (TEL-AML1) fusion sites in childhood acute lymphoblastic leukemia. 19081626 2009
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Compared to Europe, the ALL population in Nicaragua is older, has a higher proportion of poor prognostic clinical and hematological features and receives more intensive treatment, while patients with TEL/AML1 translocations and high-hyperdiploidy are clinically in the standard risk group. 19672974 2009
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Cord blood samples were also tested for the presence of the ETV6-RUNX1 translocation, the most common genetic abnormality in childhood ALL. 25764068 2015
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Core binding factor (CBF) leukemias, those with translocations or inversions that affect transcription factor genes RUNX1 or CBFB, account for ~24% of adult acute myeloid leukemia (AML) and 25% of pediatric acute lymphocytic leukemia (ALL). 22912405 2012
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia. 9664088 1998
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Deletion burden varied by subtype, with a lower frequency in high-hyperdiploid and higher frequency in ETV6-RUNX1 fusion ALL. 28202519 2017
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Despite the fact that BCP-ALL with ETV6-RUNX1 usually results in a very good prognosis, the sibs experienced divergent outcomes; a remarkable difference in one child that presented a more aggressive disease was higher leukocytosis associated with IKZF1 deletion. 25150625 2015
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Detection of the Der (21)t(12;21) chromosome forming the TEL-AML1 fusion gene in childhood acute lymphoblastic leukemia. 9498702 1997
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Dual-color interphase fluorescence in situ hybridization (FISH) with ETV6 and AML1 probes was used for the first time on a series of 159 adult patients with acute lymphoblastic leukemia (ALL), for detection of the t(12;21)(p13;q22) translocation. 11960348 2002
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia. 16330447 2005
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE EPOR mRNA is selectively and ectopically expressed in ETV6-RUNX1(+) ALL, but the presence of a functional EPOR on the cell surface and its role in leukemogenesis driven by ETV6-RUNX1 remains to be identified. 21900195 2011
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL): The spectrum of clonal heterogeneity and its impact on prognosis. 29778230 2018
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE ETV6/RUNX1-positive childhood acute lymphoblastic leukemia in China: excellent prognosis with improved BFM protocol. 30115129 2018
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE ETV6/RUNX1 (E/R) (also known as TEL/AML1) is the most frequent gene fusion in childhood acute lymphoblastic leukemia (ALL) and also most likely the crucial factor for disease initiation; its role in leukemia propagation and maintenance, however, remains largely elusive. 22028862 2011
Childhood Acute Lymphoblastic Leukemia
0.400 AlteredExpression disease BEFREE Expression of RUNX1 isoforms and its target gene BLK in childhood acute lymphoblastic leukemia. 22748822 2012
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE Fluorescence in situ hybridization (FISH) analysis was applied to detect t(12;21) using two yeast artificial chromosome probes and cosmid probes covering the TEL(ETV6) and the AML1 gene to clarify the incidence of abnormality of t(12;21) in Japanese childhood acute lymphoblastic leukemia (ALL). 9738986 1998
Childhood Acute Lymphoblastic Leukemia
0.400 AlteredExpression disease BEFREE Folylpolyglutamate synthetase (FPGS) activity was higher in B vs T lineage ALL (p<0.005), MTX influx and FPGS activity were higher in hyperdiploid vs non-hyperdiploid ALL (p<0.03), MTX influx and FPGS activity were lower in the t(12;21) (ETV6-RUNX1) subtype (p<0.05), and the ratio of FPGS to γ-glutamyl hydrolase (GGH) activity was lower in the t(1;19) (TCF3-PBX1) subtype (p<0.03) than other genetic subtypes. 21152005 2010
Childhood Acute Lymphoblastic Leukemia
0.400 GeneticVariation disease BEFREE For example, the TEL-AML1 fusion, the most common genetic abnormality in childhood acute lymphoblastic leukemia, was recently shown to be an independent, favorable prognostic factor, suggesting that patients with this abnormality are best treated with conventional antimetabolite-based therapy. 9260050 1997
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE From 1996 to 2000, we conducted a prospective study to determine the incidence and outcomes of children with TEL/AML1-positive acute lymphoblastic leukemia (ALL). 16493009 2006
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of >8,000 genes and proteins as well as Hi-C of primary patient samples from hyperdiploid and ETV6/RUNX1-positive pediatric ALL. 30944321 2019
Childhood Acute Lymphoblastic Leukemia
0.400 Biomarker disease BEFREE High expression levels of TEL-AML1 [hazard ratio (HR), 1.3; 95% confidence interval (95% CI), 1.10-1.57; P = 0.003], AML1-TEL (HR, 4.9; 95% CI, 1.99-12.40; P = 0.001) and AML1 (HR, 1.1; 95% CI, 1.03-1.22; P = 0.006) were associated with a poor long-term clinical outcome within t(12;21)+ ALL. 15837750 2005