CBR1, carbonyl reductase 1, 873

N. diseases: 100; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 Biomarker disease BEFREE Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. 28966256 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 GeneticVariation disease BEFREE Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. 23717544 2013
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 AlteredExpression disease BEFREE IHC showed CBR1 overexpression in 56 (72%) out of 78 HCC and 88 (72%) out of 123 colon cancer cases. 21056497 2011
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 AlteredExpression disease BEFREE miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer. 30931980 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.050 Biomarker disease BEFREE We also examined CBR1 inhibition by oleic acid in cellular levels: The fatty acid effectively inhibited CBR1-mediated 4-oxo-2-nonenal metabolism in colon cancer DLD1 cells and increased sensitivity to doxorubicin in the drug-resistant gastric cancer MKN45 cells that highly express CBR1. 28450226 2017