CBR1, carbonyl reductase 1, 873

N. diseases: 100; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 Biomarker group BEFREE 15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy. 21856294 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 Biomarker group BEFREE Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer. 26476372 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 Biomarker group BEFREE Use of a new tool, AHPT, in an in vitro model of peritoneal metastasis revealed that CR1 DNA inhibited cancer cell proliferation. 31025149 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 Biomarker group BEFREE IBD-CRN cases included 17 with ulcerative colitis (UC) and two with Crohn's disease (CD); nine had cancer and 10 had dysplasia. 23347191 2013
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 AlteredExpression group BEFREE Carbonyl reductase 1 (CBR1) is theorized to participate in various cellular processes, such as signal transduction, apoptosis, carcinogenesis and drug resistance, and is highly expressed in certain malignancies, including lung tumors. 29113280 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 AlteredExpression group BEFREE As AKR and CBR enzymes metabolize several drugs, and can be expressed at higher levels in obese individuals, this proof-of-principle finding has important implications across many diseases.<b>Implications:</b> Adipocyte absorption and metabolism of chemotherapies can reduce cytotoxicity in cancer microenvironments, potentially contributing to poorer survival outcomes.<i>Mol Cancer Res; 15(12); 1704-13.©2017 AACR</i>. 29117945 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.070 AlteredExpression group BEFREE Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer. 19494278 2009