CCNT2, cyclin T2, 905

N. diseases: 7; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 Biomarker group BEFREE A further investigation into the mechanism underlying the effect of miR-142-3p identified cyclin T2 (CCNT2) as a target of miR-142-3p in gastric cancers. miR-142-3p may exert its tumor suppressor role partially by downregulating CCNT2. 29849811 2018
CUI: C1629609
Disease: Age at menopause
Age at menopause
0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.010 Biomarker disease BEFREE MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2. 28409330 2017
CUI: C0175709
Disease: Centronuclear myopathy
Centronuclear myopathy
0.010 AlteredExpression disease BEFREE The observation that immunohistochemical expression of cyclin T2a was high in skeletal muscle cells, whereas it was undetectable in two cases of centronuclear myopathy, together with its chromosomal location, suggests an involvement of the cdk9-cyclin T2a complex in this disease. 11373316 2001
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases
0.010 AlteredExpression group BEFREE These results demonstrate that the CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have opposing roles in CHOP expression and CKD-induced vascular calcification. 30209133 2018
CUI: C0342649
Disease: Vascular calcification
Vascular calcification
0.010 AlteredExpression phenotype BEFREE These results demonstrate that the CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have opposing roles in CHOP expression and CKD-induced vascular calcification. 30209133 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 AlteredExpression phenotype BEFREE These results suggested that the abnormal downregulation of miR-142-3p and the subsequent increase in CCNT2 expression may have an important role in gastric cancer carcinogenesis. 29849811 2018