GDF15, growth differentiation factor 15, 9518

N. diseases: 389; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE Growth and differentiation factor 15 (GDF-15) has been associated with obesity, muscle wasting, and cachexia. 30874790 2020
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE Growth differentiation factor-15 (GDF-15) involves various pathophysiological conditions including renal dysfunction, heart failure and cachexia. 31581569 2019
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE We highlight the recent discovery of a central nervous system receptor for GDF-15, GFRAL (glial cell line-derived neurotrophic factor family receptor-α-like), an important advance with potential for novel treatments for obesity and cachexia. 30633545 2019
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype CTD_human Unsupervised identification of disease states from high-dimensional physiological and histopathological profiles. 30782979 2019
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved in placentation, appetite, and cachexia. 29563502 2018
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE Inhibiting MIC-1/GDF15 or its receptor GFRAL are high-value potential targets for treatment of anorexia/cachexia syndrome in patients whose elevated serum levels may justify its use. 30382947 2018
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. 29866502 2018
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE These results also reveal new targets for therapeutic application of GDF15 in treating obesity and cachexia. 30104250 2018
CUI: C0006625
Disease: Cachexia
Cachexia
0.380 Biomarker phenotype BEFREE MIC-1 over-expressing prostate cancer cells that grow in bone induce osteoclast formation and cachexia. 19152406 2009