Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE Furthermore, in the linear regression models with bootstrap resampling with 1000 replications, high GDF-15 levels were independently associated with testosterone deficiency in male patients with CAD. 30819257 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE Serum levels of GDF-15 were significantly increased and serum testosterone and testosterone/estradiol ratio (T/E2 ratio) were significantly decreased in CAD patients compared with controls. 30909145 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE After adjusting for confounding factors, we found that circulating GDF-15 concentrations remained positively associated with the presence of CAD (odds ratio [OR] per 1-standard deviation [SD] increase, 3.182; 95% confidence interval [CI] 1.586 to 6.382; P = .001), as did KLF4 concentrations (OR per 1-SD increase, 13.05; 95% CI 2.940 to 57.921, P = .001). 31153870 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE We conducted a Mendelian randomisation study to examine the role of GDF-15 in risk of coronary artery disease (CAD) and breast and colorectal cancer. 31161347 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE Predictive value of long-term changes of growth differentiation factor-15 over a 27-year-period for heart failure and death due to coronary heart disease. 29771963 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease. 27811204 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE In the full model (clinical variables, extent of CAD, all biomarkers), hazard ratios (95% CI) per standard deviation increase were for cTnT-hs 0.93(0.81-1.05), NT-proBNP 1.32(1.13-1.53), GDF-15 1.20(1.07-1.36) for the composite end point, driven by prediction of CVD by NT-proBNP and GDF-15. 27932413 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors. 28798540 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE Plasma levels of novel biomarkers were significantly elevated (sST2, GDF-15, H-FABP, suPAR) or inversely downregulated (fetuin A) in patients with AMI compared to a control group with excluded coronary artery disease. 28683166 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. 28245821 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE In multivariable Cox regression analysis, the independent predictors of all-cause death were rs950880 AA homozygote (p = 0.018), age (p = 0.002), log sST2 level (p = 0.014), and log GDF-15 level (p = 0.017) in CAD patients. 28110258 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE We investigated whether GDF-15 -3148C>G variant (SNP, rs4808793) is associated with a predisposition to coronary artery disease (CAD) and its severity in a Chinese population. 21312063 2011
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease CTD_human Growth-differentiation factor-15 (GDF-15) is emerging as a prognostic biomarker in patients with coronary artery disease. 20855664 2010