MED12, mediator complex subunit 12, 9968

N. diseases: 340; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 Biomarker disease PSYGENET A polymorphism of the HOPA gene within Xq13 termed HOPA(12bp) is associated with schizophrenia, mental retardation, and hypothyroidism. 20218787 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease BEFREE A polymorphism of the HOPA gene within Xq13 termed HOPA(12bp) is associated with schizophrenia, mental retardation, and hypothyroidism. 20218787 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease LHGDN In the light of this new study and the prior wealth of clinical and basic science data, we conclude that the HOPA(12bp) allele is a risk factor for schizophrenia in subjects of European ancestry and suggest that further studies to define the endophenotype and mechanisms of illness associated with this polymorphism are indicated. 17299734 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease BEFREE In the light of this new study and the prior wealth of clinical and basic science data, we conclude that the HOPA(12bp) allele is a risk factor for schizophrenia in subjects of European ancestry and suggest that further studies to define the endophenotype and mechanisms of illness associated with this polymorphism are indicated. 17299734 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 Biomarker disease PSYGENET In the light of this new study and the prior wealth of clinical and basic science data, we conclude that the HOPA(12bp) allele is a risk factor for schizophrenia in subjects of European ancestry and suggest that further studies to define the endophenotype and mechanisms of illness associated with this polymorphism are indicated. 17299734 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease LHGDN A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia. 16538184 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease BEFREE Previously, we have demonstrated that an exonic polymorphism, termed HOPA(12bp), in the Opa (Opposite Paired) domain of this gene that is critical for neuronal growth and differentiation is associated with a low risk for schizophrenia. 15108174 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 Biomarker disease PSYGENET Previously, we have demonstrated that an exonic polymorphism, termed HOPA(12bp), in the Opa (Opposite Paired) domain of this gene that is critical for neuronal growth and differentiation is associated with a low risk for schizophrenia. 15108174 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 Biomarker disease BEFREE Polymorphism analysis of HOPA: a candidate gene for schizophrenia. 14582143 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease BEFREE We were interested to know if the 12-bp duplication variant of the HOPA gene is a risk factor for mental retardation and schizophrenia in the Chinese population. 12860370 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease BEFREE We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia. 12627458 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 Biomarker disease PSYGENET Polymorphism analysis of HOPA: a candidate gene for schizophrenia. 14582143 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 Biomarker disease PSYGENET We were interested to know if the 12-bp duplication variant of the HOPA gene is a risk factor for mental retardation and schizophrenia in the Chinese population. 12860370 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease BEFREE In a prior study of the genetic basis of schizophrenia, we showed that exonic polymorphisms in HOPA were associated with increased risk of schizophrenia and hypothyroidism in a large cohort of probands from New York. 11424983 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 GeneticVariation disease BEFREE In addition, the increased frequency of HOPA variants in this population may also provide a genetic basis for the familial association of thyroid disease and schizophrenia. 10898921 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.490 Biomarker disease HPO