TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.030 GeneticVariation BEFREE Carriers of the variant C allele of rs1042522 polymorphism were at an increased risk of pancreatic cancer [odds ratio (OR) 1.73; 95% confidence interval (CI) 1.26-2.39; P = 0.001]. 20110284 2010
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.040 GeneticVariation BEFREE Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors. 31227505 2019
dbSNP: rs1131691021
rs1131691021
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors. 31227505 2019
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.040 GeneticVariation BEFREE K-ras<sup>LSL-G12D/+</sup>:: p53<sup>LSL-R172H/+</sup>:: Pdx-1-Cre (KPC) mice are an established model of pancreatic cancer that specifically express mutants of both K-ras and p53 in the pancreas by using Pdx-1-Cre. 28971839 2018
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.040 GeneticVariation BEFREE The concomitant expression of oncogenic Kras(G12D) and mutant p53 (Trp53(R172H)) in the murine pancreas results in metastatic PDA that recapitulates the cognate features of human pancreatic cancer providing an excellent animal model to identify genes required for tumor progression. 22158044 2012
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.030 GeneticVariation BEFREE The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. 21468597 2011
dbSNP: rs1131691014
rs1131691014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.020 GeneticVariation BEFREE The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. 21468597 2011
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.020 GeneticVariation BEFREE The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. 21468597 2011
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.030 GeneticVariation BEFREE This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the increased risks of digestive tract cancers, especially for Asians, and for gastric cancer, colorectal cancer and gallbladder and pancreatic cancer. 21376265 2011
dbSNP: rs1131691014
rs1131691014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.020 GeneticVariation BEFREE This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the increased risks of digestive tract cancers, especially for Asians, and for gastric cancer, colorectal cancer and gallbladder and pancreatic cancer. 21376265 2011
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.020 GeneticVariation BEFREE This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the increased risks of digestive tract cancers, especially for Asians, and for gastric cancer, colorectal cancer and gallbladder and pancreatic cancer. 21376265 2011
dbSNP: rs1555525012
rs1555525012
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE To elucidate whether and how mutant p53 acquires its gain-of-function, mutant p53 is inducibly knocked down in the SW480 colon cancer cell line, which contains mutant p53(R273H/P309S), and the MIA PaCa-2 pancreatic cancer cell line, which contains mutant p53(R248W). 18701504 2008
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.020 GeneticVariation BEFREE To elucidate whether and how mutant p53 acquires its gain-of-function, mutant p53 is inducibly knocked down in the SW480 colon cancer cell line, which contains mutant p53(R273H/P309S), and the MIA PaCa-2 pancreatic cancer cell line, which contains mutant p53(R248W). 18701504 2008
dbSNP: rs762846821
rs762846821
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.040 GeneticVariation BEFREE Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines. 14978241 2004
dbSNP: rs121913343
rs121913343
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines. 14978241 2004
dbSNP: rs121912666
rs121912666
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines. 14978241 2004
dbSNP: rs121912651
rs121912651
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.020 GeneticVariation BEFREE Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines. 14978241 2004
dbSNP: rs12947788
rs12947788
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE We previously observed an association between TP53 haplotypes based on four polymorphisms (rs17878362, rs1042522, rs12947788, and rs17884306) and the risk of colorectal and pancreatic cancer. 26226484 2015
dbSNP: rs17884306
rs17884306
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease:
Malignant neoplasm of pancreas
0.010 GeneticVariation BEFREE We previously observed an association between TP53 haplotypes based on four polymorphisms (rs17878362, rs1042522, rs12947788, and rs17884306) and the risk of colorectal and pancreatic cancer. 26226484 2015