Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Progressive Neoplastic Disease
CUI: C0677932
Disease: Progressive Neoplastic Disease
0.040 GeneticVariation BEFREE All 4 patients with progressive disease had a L858R mutation. 20430469 2011
Progressive Neoplastic Disease
CUI: C0677932
Disease: Progressive Neoplastic Disease
0.040 GeneticVariation BEFREE Eight patients received an EGFR TKI: three cases with G719X plus another mutation had partial responses (PRs) to erlotinib; of three cases with L858R plus another mutation, two displayed PRs and one (with EGFR-L858R+A871G) progressive disease (PD) to erlotinib; one NSCLC with EGFR-L861Q+E709A and one with delL747_T751+R776S had PRs to EGFR TKIs. 23242437 2013
Progressive Neoplastic Disease
CUI: C0677932
Disease: Progressive Neoplastic Disease
0.040 GeneticVariation BEFREE Here, we conducted a retrospective study to assess 375 patients whose initial biopsy indicated a TKI-sensitizing mutation (either EGFR 19del or L858R) and who developed PD after treatment with first-generation TKIs, and assayed for T790M status. 30927306 2019
Progressive Neoplastic Disease
CUI: C0677932
Disease: Progressive Neoplastic Disease
0.040 GeneticVariation BEFREE Patients with EGFR-activating mutations (del19 and L858R) that progressed using first-line gefitinib treatment were enrolled and treated with gefitinib beyond PD plus pemetrexed 500 mg/m<sup>2</sup> q3w. 30268482 2018