rs1057519847, EGFR

N. diseases: 72
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE The epidermal growth factor receptor (EGFR), when carrying an activating mutation like del19 or L858R, acts as an oncogenic driver in a subset of lung tumors. 31689114 2019
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Interestingly, acute loss of Erbb3 suppressed further growth of established EGFR(L858R)-mediated lung tumors. 25596284 2015
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Pharmacologic inhibition of β-catenin suppressed EGFR-L858R-T790M mutated lung tumor growth, and genetic deletion of the β-catenin gene dramatically reduced lung tumor formation in EGFR-L858R-T790M transgenic mice. 25164010 2014
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Finally, we showed that EGFR(L858R)/Rhob(+/+) mice developed mainly diffuse lung tumors with a lepidic pattern, whereas EGFR(L858R)/Rhob(+/-) and EGFR(L858R)/Rhob(-/-) developed a greater number of tumors, and aggressive adenocarcinomas with invasive properties. 25320360 2014
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Similarly, deficiency of Puma impeded the regression of EGFR(L858R)-driven mouse lung tumors upon inactivation of the EGFR-activating mutant. 23532334 2013
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Using specific and sensitive IHC assays, we analyzed the expression of anaplastic lymphoma kinase (ALK), EGFR L858R, and EGFR E746-A750del mutations in a subset of lung tumors, including those expressing ROS1. 22661537 2012