Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Metastatic malignant neoplasm to brain
0.050 GeneticVariation BEFREE We detected high copy numbers of epidermal growth factor receptor mutations (L858R and T790M) in the cfDNA samples from stage IV NSCLC patients who underwent stereotactic body radiation therapy to treat brain metastasis related to tyrosine kinase inhibitor (TKI) treatment failure. 29721209 2018
Metastatic malignant neoplasm to brain
0.050 GeneticVariation BEFREE <b>Conclusions:</b> NSCLC patients harboring exon 19 deletion achieved better PFS and OS than those with L858R mutation, indicating that EGFR mutation is a significant prognostic factor for advanced NSCLC patients with and without brain metastasis receiving second-line EGFR-TKIs treatment. 28367239 2017
Metastatic malignant neoplasm to brain
0.050 GeneticVariation BEFREE The posterior fossa, the anatomic "watershed areas," and the gray-white matter junction were confirmed to be more commonly affected by lung cancer brain metastases, and brain metastases with epidermal growth factor receptor (EGFR) L858R mutation occurred more often in the caudate, cerebellum, and temporal lobe than those with exon 19 deletion of EGFR. 26519739 2016
Metastatic malignant neoplasm to brain
0.050 GeneticVariation BEFREE Among EGFR-positive patients, the incidence of brain metastases was significantly higher in L858R cohort than in Del Ex19 cohort. 27402797 2016
Metastatic malignant neoplasm to brain
0.050 GeneticVariation BEFREE Among the 93 patients with BM, 41 (44%) had mutations in EGFR, including 13 exon 19 deletions and 12 L858R mutations. 20627894 2010