Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Metastatic Malignant Neoplasm to the Leptomeninges
0.030 GeneticVariation BEFREE In particular, the primary mutation, L858R, potentially predicts a higher risk of LM compared with deletion of exon 19. 30642536 2019
Metastatic Malignant Neoplasm to the Leptomeninges
0.030 GeneticVariation BEFREE We report three cases that were definitively diagnosed as LM from NSCLC with a mutation of epidermal growth factor receptor (<i>EGFR</i>) L858R. 31571928 2019
Metastatic Malignant Neoplasm to the Leptomeninges
0.030 GeneticVariation BEFREE We have recently identified an EGFR mutation E884K, in combination with L858R, in a patient with advanced lung cancer who progressed on erlotinib maintenance therapy, and subsequently had leptomeningeal metastases that responded to gefitinib. 19015641 2009