|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population.
|
11097227 |
2000 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four of the variants were found to be weakly associated with lung cancer risk with borderline significance: these were XRCC3 T241M [heterozygote odds ratio (OR), 0.89; 95% confidence interval (95% CI), 0.79-0.99 and homozygote OR, 0.84; 95% CI, 0.71-1.00] based on 3,467 cases and 5,021 controls from 8 studies, XPD K751Q (heterozygote OR, 0.99; 95% CI, 0.89-1.10 and homozygote OR, 1.19; 95% CI, 1.02-1.39) based on 6,463 cases and 6,603 controls from 9 studies, and TP53 R72P (heterozygote OR, 1.14; 95% CI, 1.00-1.29 and homozygote OR, 1.20; 95% CI, 1.02-1.42) based on 3,610 cases and 5,293 controls from 6 studies.
|
18990748 |
2008 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (Ser31Arg) and smoking on lung cancer risk.
|
17059853 |
2007 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that not Pro47Ser SNP but Arg72Pro SNP is involved in susceptibility to developing lung cancer, at least in Bangladeshi population.
|
25034526 |
2014 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G>C) of the p53 gene with lung cancer susceptibility using 175 cancer cases and 202 controls from the North Indian population.
|
23317414 |
2013 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain.
|
18336951 |
2008 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Statistical analyses revealed that polymorphisms and haplotypes in the TP53 gene, including Arg72Pro, were not significantly associated with lung cancer in a Korean population.
|
18363031 |
2008 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Despite employing a comprehensive set of statistical tests including those sensitive to the detection of differences in early survival our data provide little evidence to support the tenet that the p53 Arg72Pro polymorphism is a clinically useful prognostic marker for lung cancer.
|
17400332 |
2007 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association between genetic variation in the promoter region of MDM2 (c.-5+309G>T, rs2279744:g.G>T) and the coding region of TP53 (c.215G>C, rs1042522:g.G>C, designated Arg72Pro) and the risk of developing lung cancer.
|
16287156 |
2006 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cox regression analysis showed p53 Arg72Pro heterozygous genotype was overall an independent prognostic factor (Risk ratio of death, 2.2; P = 0.02), suggesting Pro72Pro genotype to be a potential risk factor favoring the development of lung carcinoma and that Arg72Pro genotype is independently associated with a poorer prognosis of lung cancer.
|
18181044 |
2008 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer were examined in a northern Thai population: CYP1A1 (MspI), CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (Arg72Pro), and MMP1(AluI).
|
19963114 |
2009 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis to evaluate the relationship between TP53 Arg72Pro polymorphism and lung cancer susceptibility basing on 15,647 lung cancer patients and 14,391 controls from 36 published literatures.
|
23595658 |
2013 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we hypothesized that the genetic variants in these three genes influence the predisposition of lung cancer (i.e., CCND1 G870A, CDKN2A Ala(148)Thr, TP53 Arg(72)Pro, and 16-bp repeat in intron 3) and that the effect of X-ray on lung cancer risk can be modified by the presence of these genetic variations.
|
16912209 |
2006 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
More studies stratified for lung cancer stage-genotyping interaction should be performed to clarify the role of TP53 Arg72Pro polymorphism in the development of lung cancer.
|
19623649 |
2009 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population.
|
23812725 |
2013 |
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
TP53 p.R72P genotype is a marker of poor prognosis in lung cancer.
|
29286914 |
2018 |