rs1131691014, TP53

N. diseases: 214
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Esophageal carcinoma
CUI: C0152018
Disease: Esophageal carcinoma
0.070 GeneticVariation BEFREE Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis. 26345834 2015
Esophageal carcinoma
CUI: C0152018
Disease: Esophageal carcinoma
0.070 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039 2014
Esophageal carcinoma
CUI: C0152018
Disease: Esophageal carcinoma
0.070 GeneticVariation BEFREE In the stratified analysis by ethnicity, the data suggested that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in the Asian group. 23844939 2013
Esophageal carcinoma
CUI: C0152018
Disease: Esophageal carcinoma
0.070 GeneticVariation BEFREE Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for EC risk associated with TP53 Arg72Pro polymorphism using fixed- and random-effects models. 21448430 2011
Esophageal carcinoma
CUI: C0152018
Disease: Esophageal carcinoma
0.070 GeneticVariation BEFREE In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. 20827430 2010
Esophageal carcinoma
CUI: C0152018
Disease: Esophageal carcinoma
0.070 GeneticVariation BEFREE When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significantly associated with the Pro variant of TP53 Arg72Pro in three genetic comparison models [odds ratio (OR)Pro vs. Arg=1.21, 95% confidence interval (CI): 1.05-1.39, POR=0.009; ORDominant genetic model=1.22, 95% CI: 1.09-1.37, POR=0.001; ORHomozygote model=1.40, 95% CI: 1.05-1.87, POR=0.024]. 20389250 2010
Esophageal carcinoma
CUI: C0152018
Disease: Esophageal carcinoma
0.070 GeneticVariation BEFREE This study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (SNP) in the p53 pathway (p53 Arg72Pro and MDM2 T309G) in patients with esophageal cancer, and to determine the importance of histologic subtype in the SNP-outcome relationships. 19383811 2009