|
Asthma
|
|
0.840 |
GeneticVariation
|
GWASDB |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
|
Asthma
|
|
0.840 |
GeneticVariation
|
GWASCAT |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
|
Asthma
|
|
0.840 |
GeneticVariation
|
BEFREE |
We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)).
|
20860503 |
2010 |
|
Asthma
|
|
0.840 |
GeneticVariation
|
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
Asthma
|
|
0.840 |
GeneticVariation
|
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
Allergic Reaction
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Late-onset wheeze was associated with 2 IL1RL1 SNPs (rs10208293 and rs13424006), and persistent wheeze was associated with 1 IL33 SNP (rs1342326) and 1 IL1RAP SNP (rs9290936).
|
24568840 |
2014 |
|
Hay fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-33-polymorphisms rs928413 and rs1342326 may account for an increased risk of hay fever with the age of 6 years.
|
27171815 |
2016 |
|
Asthma
|
|
0.840 |
GeneticVariation
|
BEFREE |
The presence of rs1342326 polymorphism was significantly associated with a lower risk of asthma development.
|
28985997 |
2018 |
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL33 rs1342326 polymorphism was associated with a lower childhood asthma risk in the Tunisian population and a higher IL-33 protein expression.
|
28985997 |
2018 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with BD exhibited a significantly higher prevalence of the T/G genotype of rs1342326</span> polymorphism compared with the control group.
|
30447310 |
2019 |
|
Eczema
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Asthma
|
|
0.840 |
GeneticVariation
|
BEFREE |
The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05).
|
30950351 |
2019 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05).
|
30950351 |
2019 |
|
Asthma
|
|
0.840 |
GeneticVariation
|
BEFREE |
C/C genotype of rs1342326 [OR (95% CI) 2.50 (1.33-4.69)] and A/A genotype of rs3939286 [OR (95% CI) 2.18 (1.05-4.52)] were associated with higher risk of asthma development.
|
31820077 |
2020 |
|
Adult onset asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1342326 was associated with atopic, mild and adult-onset asthma and a higher level of eosinophils in peripheral blood.
|
31820077 |
2020 |