Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Thyroid associated opthalmopathies
CUI: C0339143
Disease: Thyroid associated opthalmopathies
0.030 GeneticVariation BEFREE (i) Allele G and G/G genotype confer genetic susceptibility to GD; (ii) CTLA-4 A49G polymorphism is not associated with the development of GO; (iii) different non-genetic factors may contribute to GO in different populations. 12534352 2003
Thyroid associated opthalmopathies
CUI: C0339143
Disease: Thyroid associated opthalmopathies
0.030 GeneticVariation BEFREE The CTLA-4 SNPs (-318C/T, 49A/G, and CT60A/G) were in the same haplotype block, and the CGG haplotype was associated with GD (P = 0.0071) but not GO. 18296657 2008
Thyroid associated opthalmopathies
CUI: C0339143
Disease: Thyroid associated opthalmopathies
0.030 GeneticVariation BEFREE The G allele of A49G, the G allele of CT60, and the 280 allele of (AT)(n)-3'UTR microsatellite were significantly increased in patients with GD with thyroid-associated ophthalmopathy (TAO) compared to controls (p = 0.04, p = 0.03, and p = 0.02, respectively), however, we did not find any significant difference between TAO and non-TAO patients. 15785242 2005