|
Electrocardiogram: P-R interval
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Electrocardiogram: P-R interval
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association studies of the PR interval in African Americans.
|
21347284 |
2011 |
|
Electrocardiogram: P-R interval
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Several common variants modulate heart rate, PR interval and QRS duration.
|
20062063 |
2010 |
|
Electrocardiogram: P-R interval
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Replication testing among 6,243 Indian Asians and 5,370 Europeans confirmed that rs6795970 (G>A) is associated with prolonged cardiac conduction (longer P-wave duration, PR interval and QRS duration, P = 10(-5) to 10(-20)).
|
20062061 |
2010 |
|
QRS complex feature
|
|
0.700 |
GeneticVariation
|
GWASCAT |
52 Genetic Loci Influencing Myocardial Mass.
|
27659466 |
2016 |
|
Brugada Syndrome (disorder)
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
|
23872634 |
2013 |
|
Electrocardiography
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic variation in SCN10A influences cardiac conduction.
|
20062061 |
2010 |
|
QRS complex feature
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Several common variants modulate heart rate, PR interval and QRS duration.
|
20062063 |
2010 |
|
Atrial Fibrillation
|
|
0.020 |
GeneticVariation
|
BEFREE |
There was a significant difference in the allele distribution (p = 7.86 × 10<sup>-5</sup>) and genotype distribution (p = 1.42 × 10<sup>-5</sup>) of rs6795970 between the AF recurrence and no recurrence groups.
|
28281580 |
2017 |
|
Heart Block
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], P = 0.0005).The rs6795970 in the SCN10A gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients.
|
26104176 |
2015 |
|
Atrial Fibrillation
|
|
0.020 |
GeneticVariation
|
BEFREE |
The common variant rs6795970 in SCN10A is associated with the PR interval duration among healthy patients and those with AF.
|
24072447 |
2014 |
|
Heart Block
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also find that rs6795970 is associated with a higher risk of heart block (P < 0.05) and a lower risk of ventricular fibrillation (P = 0.01).
|
20062061 |
2010 |
|
Abdominal Pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first report linking the rs6795970 mutation with postoperative abdominal pain in humans.
|
31642403 |
2019 |
|
Lower abdominal pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
This information could be used to develop new predictive tools to optimize patient pain experience and analgesic use in the perioperative setting.<b>NEW & NOTEWORTHY</b> We present evidence that in a cohort of patients undergoing sigmoid colectomy, those homozygous for the Na<sub>V</sub>1.8 polymorphism (rs6795970) reported significantly lower abdominal pain scores than individuals with the homozygous wild-type or heterozygous genotype.
|
31642403 |
2019 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allelic frequency of only one non-synonymous SNP (rs6795970 [<i>SCN10A</i>]) approached significance in hypoalgesic IBD patients when compared to other IBD patients (<i>p</i> = 0.096, Fisher's exact test).
|
30538988 |
2018 |
|
Mechanical pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrated an association between rs6795970 (G > A; p.Ala1073Val) and higher thresholds for mechanical pain in a discovery cohort (496 subjects) and confirmed it in a larger replication cohort (1005 female subjects).
|
27590072 |
2016 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two SCN10A polymorphisms in high linkage disequilibrium (r(2) = 0.95) showed significant association with MSFC performance in patients with MS (rs6795970: p = 6.2 × 10(-4); rs6801957: p = 0.0025).
|
26740675 |
2016 |
|
Hypertrophic Cardiomyopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], P = 0.0005).The rs6795970 in the SCN10A gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients.
|
26104176 |
2015 |
|
Ventricular Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also find that rs6795970 is associated with a higher risk of heart block (P < 0.05) and a lower risk of ventricular fibrillation (P = 0.01).
|
20062061 |
2010 |