×
Entrez Id: 1495
Gene Symbol: CTNNA1
CTNNA1
Hereditary Nonpolyposis Colorectal Cancer
0.300
Biomarker
CLINGEN
×
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
Hereditary Nonpolyposis Colorectal Cancer
0.800
Biomarker
CLINGEN
Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk.25512458 2015
×
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
Hereditary Nonpolyposis Colorectal Cancer
0.700
Biomarker
CLINGEN
MLH3 has been assumed to be less important in MMR than the other HNPCC susceptibility genes MSH2, MSH6, MLH1, and PMS2, and accordingly a low-risk gene for colorectal cancer (CRC).18521850 2008
×
Entrez Id: 22909
Gene Symbol: FAN1
FAN1
Hereditary Nonpolyposis Colorectal Cancer
0.500
Biomarker
CLINGEN
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
20603073 2010
×
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
Hereditary Nonpolyposis Colorectal Cancer
0.340
Biomarker
CLINGEN
A pathology atlas of the human cancer transcriptome.
28818916 2017
×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Cancer
0.300
Biomarker
CLINGEN
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1.
11498787 2001
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Cancer
0.330
Biomarker
CLINGEN
Alterations of Chk1 and Chk2 expression in colon cancer.
18679694 2008
×
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
Hereditary Nonpolyposis Colorectal Cancer
0.350
Biomarker
CLINGEN
Because of functional similarity to Fen1, and because Exo1 is involved in DNA mismatch repair (MMR) by interaction with Msh2 and Mlh1, genes that cause hereditary nonpolyposis colorectal cancer (HNPCC ), we investigated the possibility that Exo1 might also act as a modifier to Apc(1638N).
17452984 2007
×
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Hereditary Nonpolyposis Colorectal Cancer
1.000
Biomarker
CLINGEN
Cancer risks for MLH1 and MSH2 mutation carriers.
23255516 2013
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Cancer
0.330
Biomarker
CLINGEN
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
28135145 2017
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Cancer
0.330
Biomarker
CLINGEN
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
28135145 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Cancer
0.330
Biomarker
CLINGEN
CHEK2 mutations and HNPCC-related colorectal cancer.
19876921 2010
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Cancer
0.300
Biomarker
CLINGEN
Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells.
9926925 1999
×
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
Hereditary Nonpolyposis Colorectal Cancer
0.700
Biomarker
CLINGEN
Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC.
17203173 2007
×
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
Hereditary Nonpolyposis Colorectal Cancer
0.700
Biomarker
CLINGEN
Contributions by both MLH1/MLH3 and MLH1/PMS2 complexes to mechanisms of mismatch repair-mediated tumor suppression, therefore, provide an explanation why, among MutL homologues, only germ line mutations in MLH1 are common in hereditary non-polyposis colon cancer .
16204034 2005
×
Entrez Id: 22909
Gene Symbol: FAN1
FAN1
Hereditary Nonpolyposis Colorectal Cancer
0.500
Biomarker
CLINGEN
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
20603016 2010
×
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
Hereditary Nonpolyposis Colorectal Cancer
0.800
Biomarker
CLINGEN
Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer.
22494821 2012
×
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1
Hereditary Nonpolyposis Colorectal Cancer
0.300
Biomarker
CLINGEN
Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours.
11758809 2001
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Cancer
0.330
Biomarker
CLINGEN
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
16478982 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Nonpolyposis Colorectal Cancer
0.330
Biomarker
CLINGEN
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.
15829956 2005
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Cancer
0.300
Biomarker
CLINGEN
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.
9736017 1998
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Nonpolyposis Colorectal Cancer
0.330
Biomarker
CLINGEN
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
25368522 2014
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Cancer
0.320
Biomarker
CLINGEN
E-cadherin germline mutations in familial gastric cancer.
9537325 1998
×
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
Hereditary Nonpolyposis Colorectal Cancer
0.350
Biomarker
CLINGEN
Evidence made available in this study sheds light on the pathogenesis of HNPCC , perhaps initiated by an additional MMR gene, hEXO1 .
12414623 2002
×
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
Hereditary Nonpolyposis Colorectal Cancer
0.700
Biomarker
CLINGEN
Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.
19483466 2009