×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
A gene for familial juvenile polyposis maps to chromosome 18q21.1.
9545410
1998
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.
15378062
2004
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A.
17325551
2007
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
11536076
2001
×
Entrez Id:
657
Gene Symbol:
BMPR1A
BMPR1A
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.
11381269
2001
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.
9506519
1998
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
Juvenile Polyposis Coli
0.500
Biomarker
CLINGEN
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.
16287957
2005
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
9582123
1998
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
Juvenile Polyposis Coli
0.500
Biomarker
CLINGEN
Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.
23399955
2013
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
14534577
2003
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Smad4 acts as tumor suppressor by antagonizing lymphangiogenesis in colorectal cancer.
25680269
2015
×
Entrez Id:
2022
Gene Symbol:
ENG
ENG
Juvenile Polyposis Coli
0.500
Biomarker
CLINGEN
Syndecan-1, Epithelial-Mesenchymal Transition Markers (E-cadherin/β-catenin) and Neoangiogenesis-related Proteins (PCAM-1 and Endoglin) in Colorectal Cancer.
27127133
2016
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
9482899
1998
×
Entrez Id:
4089
Gene Symbol:
SMAD4
SMAD4
Juvenile Polyposis Coli
0.800
Biomarker
CLINGEN
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.
15235019
2004