×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
30320580 2018
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.
21157020 2011
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
pH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations.
21980910 2011
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease.
21209907 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
28448946 2017
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Here, we generated a double homozygous knock-in mouse model that incorporates the Swedish familial Alzheimer's disease mutations and converts mouse Abeta to the human sequence in amyloid precursor protein and had the P264L familial Alzheimer's disease mutation in presenilin-1.
16651627 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
15591071 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Vitamin E protects nerve cells from amyloid beta protein toxicity.
1497677 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
"How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD."
17430250 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
17239395 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
16204253 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
16969627 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.
20640797 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.
19818510 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
18583042 2008
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
12572668 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model.
22507317 2012
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
20157255 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
27117003 2016
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Recombinants between the APP gene and the AD locus have been reported which seemed to exclude it as the site of the mutation causing familial AD .
1671712 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
16325427 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease .
1678058 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
High performance plasma amyloid-β biomarkers for Alzheimer's disease.
29420472 2018
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
15993441 2005