Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.010 AlteredExpression LHGDN Over expression of transforming growth factor-alpha and epidermal growth factor receptor in human hepatic cirrhosis tissues. 18507100

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0085293
Disease: Hepatitis E
Hepatitis E
0.010 Biomarker LHGDN The hepatitis E virus ORF3 protein modulates epidermal growth factor receptor trafficking, STAT3 translocation, and the acute-phase response. 18448545

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0206727
Disease: Nerve Sheath Tumors
Nerve Sheath Tumors
0.010 Biomarker LHGDN The EGFR ligands transforming growth factor alpha and EGF were more strongly expressed in MPNSTs than in neurofibromas. 18650488

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.010 GeneticVariation LHGDN However, no significant relationship between the number of (CA)n repeats of EGFR intron 1 (both alleles < 20 or any allele > or = 20) and the risk of ACS was observed (adjusted OR = 0.97, 95% CI: 0.58-1.64, adjusted P = 0.911). 18664296

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0006145
Disease: Breast Diseases
Breast Diseases
0.010 Biomarker LHGDN The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions. 17164758

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007117
Disease: Basal cell carcinoma
Basal cell carcinoma
0.010 Biomarker LHGDN Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. 17525275

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms
0.010 AlteredExpression LHGDN Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. 17549377

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017639
Disease: Gliosis
Gliosis
0.010 Biomarker LHGDN Comparison of numerical change of epidermal growth factor receptor gene among pre- and postradiation glioma, and gliosis, and its clinical use. 18095139

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0206633
Disease: Angiomyolipoma
Angiomyolipoma
0.010 GeneticVariation LHGDN Protein expression and mutational analysis of epidermal growth factor receptor in renal angiomyolipomas. 17685929

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C2937421
Disease: Prostatic Hyperplasia
Prostatic Hyperplasia
0.010 Biomarker LHGDN Immunohistochemical study of the expression of epidermal growth factor receptor in benign prostatic hypertrophy, prostatic intraepithelial neoplasia and prostatic carcinoma. 17183836

2006

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.010 GeneticVariation LHGDN Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair. 15100232

2004

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0018621
Disease: Hay fever
Hay fever
0.010 AlteredExpression LHGDN Epidermal growth factor receptor - but not histamine receptor - is upregulated in seasonal allergic rhinitis. 12757445

2003

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0029132
Disease: Disorder of the optic nerve
Disorder of the optic nerve
0.010 Biomarker LHGDN Our results suggest that activation and nuclear localization of EGFR may be needed for induction of NOS-2 in response to elevated intraocular pressure in glaucomatous optic neuropathy. 12828935

2003

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.010 AlteredExpression LHGDN Epidermal growth factor receptor - but not histamine receptor - is upregulated in seasonal allergic rhinitis. 12757445

2003

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0032019
Disease: Pituitary Neoplasms
Pituitary Neoplasms
0.010 Biomarker LHGDN [Detection of serum epidermal growth factor receptor in the diagnosis of proliferation of pituitary adenomas]. 12133497

2002

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0206706
Disease: Verrucous carcinoma
Verrucous carcinoma
0.010 AlteredExpression LHGDN EGFR expression was noted in 25% of VH, 54% of VC, 40% of well-differentiated SCC (WDSCC), and 100% of moderately and poorly differentiated SCC (MDSCC/PDSCC). 12607604

2002

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C3714644
Disease: Thymus Neoplasms
Thymus Neoplasms
0.010 AlteredExpression LHGDN EGFR is often strongly expressed and is a potential therapeutic target in patients with malignant thymic tumors. 11935304

2002

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms
0.020 Biomarker LHGDN PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling. 18261460

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0042138
Disease: Uterine Neoplasms
Uterine Neoplasms
0.020 Biomarker LHGDN MMTV-EGF receptor transgene promotes preneoplastic conversion of multiple steroid hormone-responsive tissues. 17960555

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0242216
Disease: Biliary calculi
Biliary calculi
0.020 AlteredExpression LHGDN Increased expression of mucin 5AC mRNA and decreased expression of epidermal growth-factor receptor mRNA in gallstone patients. 18285671

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0206651
Disease: Clear Cell Sarcoma of Soft Tissue
Clear Cell Sarcoma of Soft Tissue
0.020 GeneticVariation LHGDN Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. 17646270

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0242216
Disease: Biliary calculi
Biliary calculi
0.020 Biomarker LHGDN MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder. 17148666

2006

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Prostatic Intraepithelial Neoplasias
0.020 Biomarker LHGDN EGFR positivity was observed in all the cases (100%) of BPH and PIN and in only 10 cases (28.5%) of prostatic carcinoma. 17183836

2006

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections
0.020 Biomarker LHGDN Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathway. 16115866

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms
0.020 AlteredExpression LHGDN Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. 15791567

2005