×
Entrez Id: 9531
Gene Symbol: BAG3
BAG3
leukemia
0.010
Biomarker
LHGDN
Our results indicate that knocking down BAG3 gene is a promising new approach to enhance the therapeutic potency of Bortezomib in leukemia .
19111544 2009
×
Entrez Id: 55859
Gene Symbol: BEX1
BEX1
leukemia
0.010
AlteredExpression
LHGDN
Inhibition of apoptosis by downregulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/Abl+ leukemic cells.
19028701 2009
×
Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
leukemia
0.010
GeneticVariation
LHGDN
Taken together, aberrant methylation of p16 and EDNRB was highly prevalent in leukemia patients in Taiwan.
18551992 2008
×
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
leukemia
0.010
AlteredExpression
LHGDN
Hsp70 was found to be expressed on the cell surface of leukemia cell lines compared with normal cells.18297536 2008
×
Entrez Id: 26036
Gene Symbol: ZNF451
ZNF451
leukemia
0.010
AlteredExpression
LHGDN
ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.
18656483 2008
×
Entrez Id: 7068
Gene Symbol: THRB
THRB
leukemia
0.010
AlteredExpression
LHGDN
Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor.
18239067 2008
×
Entrez Id: 29843
Gene Symbol: SENP1
SENP1
leukemia
0.010
Biomarker
LHGDN
The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.
18474224 2008
×
Entrez Id: 7415
Gene Symbol: VCP
VCP
leukemia
0.010
AlteredExpression
LHGDN
The findings demonstrated that monocytic differentiation and G0/G1 growth arrest in human U937 leukemia cells was accompanied by an increase in VCP /p97 expression and a distinct subcellular distribution to be reverted during retrodifferentiation.
18279508 2008
×
Entrez Id: 3810
Gene Symbol: KIR2DS5
KIR2DS5
leukemia
0.010
Biomarker
LHGDN
In the latter group, the stimulatory KIR2DS5 gene was associated with improved leukemia free survival (p=0.007; hazard ratio 4.3; 95% confidence interval 1.3-6.7) and lower relapse rates (p=0.028; HR 4.3, 95% CI 1.1-9.1).
18555529 2008
×
Entrez Id: 7187
Gene Symbol: TRAF3
TRAF3
leukemia
0.010
GeneticVariation
LHGDN
Somatic mutation of TRAF3 gene is rare in common human cancers and acute leukemias .
18607851 2008
×
Entrez Id: 160728
Gene Symbol: SLC5A8
SLC5A8
leukemia
0.010
GeneticVariation
LHGDN
DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication.
18566324 2008
×
Entrez Id: 4773
Gene Symbol: NFATC2
NFATC2
leukemia
0.010
Biomarker
LHGDN
Selective activation of NFAT by promyelocytic leukemia protein.
18246125 2008
×
Entrez Id: 348
Gene Symbol: APOE
APOE
leukemia
0.010
GeneticVariation
LHGDN
The beneficial effect of APOE4 in CLL survival is likely mediated through APOE4 allele-specific regulation of leukemia cell apoptosis.
18784741 2008
×
Entrez Id: 3934
Gene Symbol: LCN2
LCN2
leukemia
0.010
Biomarker
LHGDN
These findings demonstrate that lipocalin 2 has at least two functions related to tumorigenesis, one involving apoptosis induction of normal hematopoietic cells and the other being tissue invasion by leukemia cells.
18663364 2008
×
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
leukemia
0.010
Biomarker
LHGDN
PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.
19111660 2008
HSP90AB1
leukemia
0.010
GeneticVariation
LHGDN
Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias.
18591256 2008
×
Entrez Id: 113235
Gene Symbol: SLC46A1
SLC46A1
leukemia
0.010
PosttranslationalModification
LHGDN
The potential translational implications of the restoration of PCFT expression in chemotherapy of leukemia are discussed.
18817749 2008
×
Entrez Id: 55120
Gene Symbol: FANCL
FANCL
leukemia
0.010
GeneticVariation
LHGDN
Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia .
18607065 2008
×
Entrez Id: 7468
Gene Symbol: NSD2
NSD2
leukemia
0.010
AlteredExpression
LHGDN
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.
18172012 2008
×
Entrez Id: 9638
Gene Symbol: FEZ1
FEZ1
leukemia
0.010
Biomarker
LHGDN
In summary, our data suggest that FEZ1 has an important centrosomal function and supply new mechanistic insights to the formation of flower-like nuclei, which are a phenotypical hallmark of human leukemia cells.
18439996 2008
APOBEC3C
leukemia
0.010
Biomarker
LHGDN
Species-specific restriction of apobec3-mediated hypermutation.
18032489 2008
×
Entrez Id: 4102
Gene Symbol: MAGEA3
MAGEA3
leukemia
0.010
AlteredExpression
LHGDN
mRNA expression of MAGE-A3 gene in leukemia cells.
16806467 2007
×
Entrez Id: 5724
Gene Symbol: PTAFR
PTAFR
leukemia
0.010
Biomarker
LHGDN
Functional platelet-activating factor receptors in immature forms of leukemic blasts.
16837045 2007
×
Entrez Id: 10180
Gene Symbol: RBM6
RBM6
leukemia
0.010
GeneticVariation
LHGDN
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.
17360941 2007
×
Entrez Id: 29102
Gene Symbol: DROSHA
DROSHA
leukemia
0.010
AlteredExpression
LHGDN
Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.
17581865 2007