Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome. 18624351

2008
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.220 Biomarker MGD

Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. 19284971

2009
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. 18787106

2008
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice. 19700744

2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.210 Biomarker MGD Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. 1436033

1992
Entrez Id: 6768
Gene Symbol: ST14
ST14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD

Entrez Id: 6097
Gene Symbol: RORC
RORC
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD

Entrez Id: 4792
Gene Symbol: NFKBIA
NFKBIA
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. 20696914

2010
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD T-cell receptor repertoire of infiltrating T cells in lachrymal glands, salivary glands and kidneys from alymphoplasia (aly) mutant mice: a new model for Sjögren's syndrome. 9010048

1996
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. 14764671

2004
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Homeostatic regulation of intestinal villous epithelia by B lymphocytes. 11884426

2002
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Mammary glands of Aly mice: developmental changes and lactation-related expression of specific proteins, alpha-casein, GLyCAM-1 and MAdCAM-1. 10910194

2000
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. 12810685

2003
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Nematode infection in Alymphoplasia (aly) mice: worm species-dependent differential effect of defects of the gut-associated lymphatic tissue system. 16640660

2006
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Impaired function of dendritic cells in alymphoplasia (aly/aly) mice for expansion of CD25+CD4+ regulatory T cells. 17060023

2006
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD aly/aly mice: a unique model of biliary disease. 9620319

1998
Entrez Id: 9020
Gene Symbol: MAP3K14
MAP3K14
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Structure of thymic cysts in congenital lymph nodes-lacking mice. 17986312

2008
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. 16413168

2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon. 15613333

2005
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice. 17207605

2006
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance. 16709807

2006
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. 22590468

2012
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice. 17207605

2006
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.200 Biomarker MGD CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. 12196288

2002