Gene Gene Full Name DSI g DPI g pLI Disease Type Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 8654
Gene Symbol: PDE5A
PDE5A
phosphodiesterase 5A 0.513 0.731 1.1E-04
Idiopathic pulmonary arterial hypertension
disease 0.100 None 0.960 25 0 2007 2020
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
endothelin 1 0.380 0.846 0.46
Idiopathic pulmonary arterial hypertension
disease 0.100 None 1.000 24 0 2006 2019
Entrez Id: 5053
Gene Symbol: PAH
PAH
phenylalanine hydroxylase 0.516 0.769 6.4E-23
Idiopathic pulmonary arterial hypertension
disease 0.100 None 1.000 24 0 2010 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
hypoxia inducible factor 1 subunit alpha 0.327 0.923 0.98
Idiopathic pulmonary arterial hypertension
disease 0.100 None 1.000 23 0 2008 2019
Entrez Id: 857
Gene Symbol: CAV1
CAV1
caveolin 1 0.388 0.885 8.3E-03
Idiopathic pulmonary arterial hypertension
disease 0.700 moderate 0.955 22 0 2007 2019
Entrez Id: 3777
Gene Symbol: KCNK3
KCNK3
potassium two pore domain channel subfamily K member 3 0.584 0.654 0.90
Idiopathic pulmonary arterial hypertension
disease 0.700 strong 0.952 21 0 2012 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
interleukin 6 0.248 0.962 0.32
Idiopathic pulmonary arterial hypertension
disease 0.100 None 1.000 21 0 2007 2019
Entrez Id: 5739
Gene Symbol: PTGIR
PTGIR
prostaglandin I2 receptor 0.711 0.423 8.9E-04
Idiopathic pulmonary arterial hypertension
disease 0.100 None 1.000 19 0 2017 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
peroxisome proliferator activated receptor gamma 0.358 0.885 2.9E-02
Idiopathic pulmonary arterial hypertension
disease 0.200 None 1.000 17 0 2008 2020
Entrez Id: 6590
Gene Symbol: SLPI
SLPI
secretory leukocyte peptidase inhibitor 0.449 0.846 9.0E-04
Idiopathic pulmonary arterial hypertension
disease 0.100 None 0.933 15 0 2001 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
tumor necrosis factor 0.231 0.962 0.80
Idiopathic pulmonary arterial hypertension
disease 0.100 None 1.000 15 0 2012 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
transforming growth factor beta 1 0.287 0.962 3.7E-02
Idiopathic pulmonary arterial hypertension
disease 0.100 None 1.000 11 0 2001 2020
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
galectin 3 0.392 0.846 2.3E-05
Idiopathic pulmonary arterial hypertension
disease 0.100 None 0.900 10 0 2017 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
AKT serine/threonine kinase 1 0.311 0.962 0.98
Idiopathic pulmonary arterial hypertension
disease 0.090 None 1.000 9 0 2014 2019
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
growth differentiation factor 2 0.529 0.731 2.5E-03
Idiopathic pulmonary arterial hypertension
disease 0.190 None 1.000 9 0 2015 2020
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta 0.319 0.885 1.00
Idiopathic pulmonary arterial hypertension
disease 0.080 None 1.000 8 0 2016 2019
Entrez Id: 406987
Gene Symbol: MIR204
MIR204
microRNA 204 0.487 0.808
Idiopathic pulmonary arterial hypertension
disease 0.080 None 1.000 8 0 2011 2020
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta 0.322 0.885 1.00
Idiopathic pulmonary arterial hypertension
disease 0.080 None 1.000 8 0 2016 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 0.320 0.885 1.4E-06
Idiopathic pulmonary arterial hypertension
disease 0.080 None 1.000 8 0 2016 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha 0.292 0.923 1.00
Idiopathic pulmonary arterial hypertension
disease 0.080 None 1.000 8 0 2016 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
estrogen receptor 1 0.324 0.962 1.00
Idiopathic pulmonary arterial hypertension
disease 0.070 None 0.857 7 0 2010 2020
Entrez Id: 4093
Gene Symbol: SMAD9
SMAD9
SMAD family member 9 0.666 0.308 6.4E-05
Idiopathic pulmonary arterial hypertension
disease 0.660 None 0.857 7 0 2009 2018
Entrez Id: 2305
Gene Symbol: FOXM1
FOXM1
forkhead box M1 0.441 0.769 7.4E-04
Idiopathic pulmonary arterial hypertension
disease 0.070 None 1.000 7 0 2018 2020
Entrez Id: 50507
Gene Symbol: NOX4
NOX4
NADPH oxidase 4 0.471 0.885 5.8E-20
Idiopathic pulmonary arterial hypertension
disease 0.070 None 1.000 7 0 2016 2019
Entrez Id: 9496
Gene Symbol: TBX4
TBX4
T-box transcription factor 4 0.576 0.731 0.50
Idiopathic pulmonary arterial hypertension
disease 0.460 strong 1.000 7 0 2013 2020