Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. 15993441

2005
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide. 15591071

2005
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. 15590663

2005
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. 12572668

2003
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. 12852432

2003
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. 12746438

2003
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). 12192006

2002
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Vitamin E protects nerve cells from amyloid beta protein toxicity. 1497677

1992
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease. 1678058

1991
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.500 Biomarker CTD_human Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. 1671712

1991