×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
CausalMutation
CGI
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
Biomarker
HPO
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
There was complete concordance between p53 gene mutation and p53 protein accumulation in the 15 snap-frozen carcinomas and in both breast carcinoma cell lines.
1317462 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Some recent data on the Wilms' tumor gene, WT1, and on the involvement of the p53 gene in breast cancer are presented, and the importance of genomic imprinting in contributing to the excess of suppressor gene mutations in chromosomes of paternal origin is considered.
1336726 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
AlteredExpression
BEFREE
In this study, we evaluated the prognostic significance of p53 protein overexpression in patients with ANN breast cancer .
1352359 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
Two distinct mechanisms alter p53 in breast cancer : mutation and nuclear exclusion.
1353891 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
One germ-line mutation was found in 136 patients and so we conclude that constitutional mutation of p53 may be an uncommon etiological factor in breast cancer .
1394133 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot.
1423285 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
AlteredExpression
BEFREE
Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer : an immunohistochemical study.
1453267 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
AlteredExpression
BEFREE
Retinoblastoma and p53 gene product expression in breast carcinoma : immunohistochemical analysis and clinicopathologic correlation.
1468776 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
We have investigated the expression of ras p21, Rb1 and p53 proteins in human breast cancer patients immunohistochemically, and correlated the results with a range of clinical and pathological parameters.
1567185 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
AlteredExpression
BEFREE
Using this reagent we have found that aberrant expression of p53 is a frequent feature of human breast cancer .
1569122 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families.
1570151 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
We examined 126 consecutive patients who developed breast cancer at or before the age of 40 for mutations of p53 within conserved regions of the gene.
1581912 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Moreover, somatically acquired p53 mutations and gene deletions are common feature in breast cancer of sporadic origin.
1587536 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Screening for germ line TP53 mutations in breast cancer patients.
1591732 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
The p53 gene, a putative tumor suppressor gene located at 17p13, was examined for aberrations to determine whether it is the target for the 17p LOH in breast cancer .
1673792 1991
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
There was no significant correlation with c-erbB-2 protein expression or retinoblastoma protein loss. p53 protein was detected in a high proportion of cells in three of the six comedo ductal carcinomas in situ studied but either not at all or at a lower level in tumours of the cribriform type. p53 mutations are common in breast carcinomas , but heterogeneity within individual tumours is frequent.
1684809 1991
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
Biomarker
BEFREE
Thus, abnormal p53 is the commonest oncogene abnormality described in breast cancer .
1685017 1991
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Immunohistochemical data suggest that p53 mutation is the commonest genetic alteration so far detected in primary breast cancer .
1694291 1990
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas .
1712853 1991
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
We detected p53 mutations in 14 (32.6%) of 44 breast carcinomas .
1734086 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Immunohistochemical analysis is a simple method which reliably predicts the presence of most p53 gene mutations in breast cancer specimens.
1745051 1991
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
AlteredExpression
BEFREE
Abnormalities in p53 expression were found in 19 out of 40 Fine Needle Aspiration (FNA) smears with infiltrating ductal breast carcinomas .
1746898 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Breast Carcinoma
0.900
GeneticVariation
BEFREE
Maintenance of p53 alterations throughout breast cancer progression.
1850660 1991