Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration. 23112570

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Variants in the VEGFA gene and treatment outcome after anti-VEGF treatment for neovascular age-related macular degeneration. 23149126

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE To determine optical coherence tomography signs associated with macular atrophy (MA) in eyes with neovascular age-related macular degeneration and pigment epithelial detachments treated with vascular endothelial growth factor inhibitors. 30589663

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors. 29305324

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE CFH Y402H and VEGF Polymorphisms and Anti-VEGF Treatment Response in Exudative Age-Related Macular Degeneration. 27404493

2016

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE VEGF polymorphisms are associated with neovascular age-related macular degeneration. 16940309

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Pharmacogenetics of <i>VEGF-A</i> polymorphism rs833061 may play a positive role in response to anti-VEGF therapy for nAMD. 28400373

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE To investigate the association between the vascular endothelial growth factor (VEGF) gene and response to either intravitreal bevacizumab (IVB) or photodynamic therapy with intravitreal triamcinolone acetonide and IVB (triple therapy) for neovascular age-related macular degeneration (AMD). 21744122

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE To determine whether there is an association between CFH, ARMS2, HTRA1, VEGF, SERPING1 or C3 genotypes and patient response to treatment with intravitreal bevacizumab for neovascular age-related macular degeneration (AMD). 22594510

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE To assess the prevalence and characteristics associated with macular atrophy (MA) in eyes with neovascular age-related macular degeneration (nAMD) treated with vascular endothelial growth factor (VEGF) inhibitors. 31843790

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Intravitreal injections of antibody-based biologics targeting vascular endothelial growth factor (VEGF) are highly effective and have markedly decreased the risk of visual impairment associated with prevalent retinal diseases, such as neovascular age-related macular degeneration and diabetes macular oedema. 31792234

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration. 28926193

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE With the exception of several limitations, the present study showed evidence of an association between the VEGF +405 G/C polymorphism and nAMD in Malaysian subjects. 28926292

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE VEGF-A polymorphisms predict short-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration. 23570466

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. 20019880

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE To investigate the association of treatment assignment (intravitreal aflibercept vs ranibizumab) and baseline characteristics with fellow eye conversion to nAMD in the VEGF (Vascular Endothelial Growth Factor) Trap-Eye: Investigation of Efficacy and Safety in Wet AMD (VIEW) studies. 31294771

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Vascular endothelial growth factor gene polymorphisms and risk of neovascular age-related macular degeneration in a Chinese cohort. 20847577

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Three Variants of or near VEGF-A Gene are Not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Han Chinese Population. 24303777

2015

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE To evaluate the role of vascular endothelial growth factor (VEGF) gene polymorphisms in exudative age-related macular degeneration (AMD). 19896188

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration. 21558292

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE VEGF gene polymorphism and response to intravitreal ranibizumab in neovascular age-related macular degeneration. 24157918

2014

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION PATIENTS WITH VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS IN EVERYDAY PRACTICE: Identification of Health Care Constraints in Germany-The PONS Study. 28489692

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 GeneticVariation BEFREE Subfoveal Choroidal Thickness in Eyes with Neovascular Age-Related Macular Degeneration Treated with Anti-Vascular Endothelial Growth Factor Agents. 29768266

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 Biomarker BEFREE To report and compare 10-year treatment outcomes of vascular endothelial growth factor (VEGF) inhibitors for neovascular age-related macular degeneration (nAMD) from Australia and New Zealand (ANZ) and Switzerland. 31606444

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
Exudative age-related macular degeneration
0.100 Biomarker BEFREE AXT107 reduced the VEGF-induced vascular leakage that underlies macular edema in ischemic retinopathies and NVAMD. 28100839

2017