Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.630 GeneticVariation BEFREE FGFR1 CNG (10.7%), FGFR1 mutation (2.7%), FGFR2 mutation (2.7%), FGFR4 mutation (5.3%), and FGFR3 fusion (1.3%) were detected in LSCC specimens by NGS. 27581340

2016
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.630 GeneticVariation GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191

2016
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.630 GeneticVariation BEFREE Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. 23786770

2013
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.630 GeneticVariation UNIPROT

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.630 GeneticVariation BEFREE FGFR2 and other FGFR kinase family gene alterations have been found in both lung squamous cell carcinoma and lung adenocarcinoma, although mouse models of FGFR-driven lung cancers have not been reported. 25035393

2014
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.630 CausalMutation CGI

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.630 GeneticVariation CLINVAR Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. 23786770

2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation CLINVAR Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. 22753918

2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE Therefore, in contrast to advanced LADC, EGFR mutation testing may not be necessarily performed upfront in advanced LSQC because not only the mutation rate is low, but also the predictive value is insufficient. 25053390

2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE Detection of the EGFR mutation in exhaled breath condensate from a heavy smoker with squamous cell carcinoma of the lung. 21684624

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE Ten of 215 pure SQCCs (4.7%; 95% CI, 2.3%-8.4%) harbored mutations, including seven with PIK3CA, and each with AKT1, DDR2, and EGFR. 24158231

2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung. 17186532

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE This study was focused on EGFR somatic mutations and amplifications in squamous cell lung cancer. 20635059

2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 Biomarker BEFREE Detection and monitoring of driver mutations by next-generation sequencing in squamous cell lung cancer patient and possible predictive biomarker of third generation EGFR-tyrosine kinase inhibitors. 29143497

2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma. 31660987

2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 Biomarker BEFREE Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice. 17533397

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations. 26216950

2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE EGFR mutation is associatedwith short PFS and the brain is the most common site of distant metastasis in patients with stage III non- squamous cell lung cancer treated with CCRT. 29914238

2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE EGFR rs2233947 correlated with lung cancer in males, smokers, and in the squamous cell carcinoma lung cancer subtype (P<0.01). 31518089

2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 Biomarker BEFREE Significant differences in NIC, K values, and calcium content were observed between the EGFR-positive and EGFR-negative groups among patients with SC. 29752156

2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 AlteredExpression BEFREE Finally, an inverse correlation was observed between Fhit and phospho-EGFR levels in a cohort of human squamous cell lung carcinoma specimens. 24464917

2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 CausalMutation CLINVAR Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma. 20942962

2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE To analyze the distribution of epidermal growth factor receptor (<i>EGFR</i>) mutations; characterize the clinical and imageological features of lung squamous cell carcinoma (LSCC) in a large population of patients; and assess correlations between clinical and imageological characteristics and clinical outcomes of LSCC patients harboring <i>EGFR</i> mutations. 31695493

2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 GeneticVariation BEFREE The aim of this study was to evaluate the status of erlotinib treatment and EGFR mutation in lung SCC patients. 22420950

2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.500 Biomarker BEFREE Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An <i>EGFR</i> Sensitizing Mutation. 31802898

2019