×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
1978757 1990
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.
1565143 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.
1631137 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
1565144 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
1565144 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Screening for germ line TP53 mutations in breast cancer patients.
1591732 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Screening for germ line TP53 mutations in breast cancer patients.
1591732 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.
7887414 1995
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Molecular analysis of the TP53 gene in Barrett's adenocarcinoma.
8829627 1996
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Three germline mutations in the TP53 gene.
9067756 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Li-Fraumeni syndrome--a molecular and clinical review.
9218725 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.
9047394 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Simple identification of dominant p53 mutants by a yeast functional assay.
9364015 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.
9242456 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Comprehensive mutational scanning of the p53 coding region by two-dimensional gene scanning.
9667734 1998
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.
9764816 1998
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A patient with 17 primary tumours and a germ line mutation in TP53: tumour induction by adjuvant therapy?
11315715 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Absence of germline p16(INK4a) alterations in p53 wild type Li-Fraumeni syndrome families.
10922393 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
P53 germline mutations in childhood cancers and cancer risk for carrier individuals.
10864200 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Tissue-specific expression of SV40 in tumors associated with the Li-Fraumeni syndrome.
11494139 2001
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li-Fraumeni-like syndrome.
11370630 2001
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites.
11139324 2001
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition.
11479205 2001
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer.
11753428 2002
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Tumour p53 mutations exhibit promoter selective dominance over wild type p53.
11896595 2002