Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2006
Gene Symbol: ELN
ELN
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.400 Biomarker HPO

Entrez Id: 4015
Gene Symbol: LOX
LOX
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.340 Biomarker HPO

Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.160 Biomarker HPO

Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.150 Biomarker HPO

Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.130 Biomarker HPO

Entrez Id: 7043
Gene Symbol: TGFB3
TGFB3
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.120 Biomarker HPO

Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.110 Biomarker HPO

Entrez Id: 4629
Gene Symbol: MYH11
MYH11
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.110 Biomarker HPO

Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.110 Biomarker HPO

Entrez Id: 4638
Gene Symbol: MYLK
MYLK
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.110 Biomarker HPO

Entrez Id: 59
Gene Symbol: ACTA2
ACTA2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.110 Biomarker HPO

Entrez Id: 4144
Gene Symbol: MAT2A
MAT2A
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.100 Biomarker HPO

Entrez Id: 2301
Gene Symbol: FOXE3
FOXE3
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.100 Biomarker HPO

Entrez Id: 8076
Gene Symbol: MFAP5
MFAP5
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.100 Biomarker HPO

Entrez Id: 286053
Gene Symbol: NSMCE2
NSMCE2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.100 Biomarker HPO

Entrez Id: 5592
Gene Symbol: PRKG1
PRKG1
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.100 Biomarker HPO

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.100 Biomarker HPO

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.350 AlteredExpression BEFREE <i>ACE2</i> expression was lower in infrarenal biopsies of patients with AAA than organ donors. 28935757

2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.010 Biomarker BEFREE (3)AS-IV inhibited Bap-induced RAW264.7 macrophage cells activation by inhibiting oxidative stress and NF-κB activation through phosphatidylinositol 3-kinase (PI3-K)/AKT pathway.AS-IV is a potential preventive agent for cigarette smoking-related AAA. 29872394

2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.100 AlteredExpression BEFREE AAA tissue contained higher levels of IL-10 compared to AOD tissue (P < 0.05). 11735270

2001
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 AlteredExpression BEFREE AAA wall expressed significantly more stromelysin-1 (MMP-3) (mean log(10) ratio [copy enzyme cDNA/copy GAPDH cDNA], -1.9; range, -3.3 to -0.7) than the AOD wall (mean, 4; range, -5.7 to -2.4), P<0.005. 11815431

2002
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.010 AlteredExpression BEFREE AAA wall expressed significantly more stromelysin-1 (MMP-3) (mean log(10) ratio [copy enzyme cDNA/copy GAPDH cDNA], -1.9; range, -3.3 to -0.7) than the AOD wall (mean, 4; range, -5.7 to -2.4), P<0.005. 11815431

2002
Entrez Id: 2006
Gene Symbol: ELN
ELN
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.400 Biomarker BEFREE Abdominal aortic aneurysm (AAA) is characterized by dilatation of arterial walls, which is accompanied by degradation of elastin and collagen molecules. 16127278

2005
Entrez Id: 2006
Gene Symbol: ELN
ELN
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.400 Biomarker BEFREE AAA lesions in Mcpt4(-/-) mice had fewer inflammatory cells and less apoptosis, angiogenesis, and elastin fragmentation than those of WT mice. 19720934

2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.050 AlteredExpression BEFREE Abdominal aortic aneurysm (AAA) development is associated with increased angiogenesis and overexpression of vascular endothelial growth factor (VEGF). 20471768

2010