×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Uncommon epidermal growth factor receptor mutations in non-small cell lung cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistance.
23485129
2013
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids.
18372921
2008
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
The epidermal growth factor receptor D761Y mutation and effect of tyrosine kinase inhibitor.
17545553
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
22897852
2012
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases.
26372703
2015
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer.
23548132
2013
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib.
18089823
2007
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer.
16730855
2006
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
16533793
2006
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Differential sensitivities to tyrosine kinase inhibitors in NSCLC harboring EGFR mutation and ALK translocation.
22622260
2012
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues.
20926413
2011
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Erlotinib response in an NSCLC patient with a novel compound G719D+L861R mutation in EGFR.
23945392
2013
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib.
18628075
2008
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations.
21398618
2011
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.
19147750
2009
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
16187797
2005
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population.
23800712
2013
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
15118073
2004
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
16474404
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations.
19396835
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
20609353
2010
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.
22235099
2012
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
In silico identification of significant detrimental missense mutations of EGFR and their effect with 4-anilinoquinazoline-based drugs.
19455431
2010
×
Entrez Id:
1956
Gene Symbol:
EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.
17653080
2008